Cumulative <i>Mycobacterium tuberculosis</i> Infection Incidence (Measured Primarily by Tuberculin Skin Test) Among Infants With Human Immunodeficiency Virus Exposure: Observational Follow-up of an Isoniazid Prophylaxis Trial-Reference-Cited by-同舟云学术

Cumulative Mycobacterium tuberculosis Infection Incidence (Measured Primarily by Tuberculin Skin Test) Among Infants With Human Immunodeficiency Virus Exposure: Observational Follow-up of an Isoniazid Prophylaxis Trial

Published:2022-05-24 Issue:12 Volume:75 Page:2253-2256
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

LaCourse Sylvia M¹²^ORCID,Escudero Jaclyn N²,Mecha Jerphason³,Warr A J⁴,Richardson Barbra A²⁵,Carimo Naziat²,Cranmer Lisa M⁶⁷,Maleche-Obimbo Elizabeth²⁸,Matemo Daniel³,Kinuthia John²³⁹,Hawn Thomas R¹,John-Stewart Grace¹²¹⁰¹¹

Affiliation:

1. Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington , Seattle, Washington , USA

2. Department of Global Health, University of Washington , Seattle, Washington , USA

3. Medical Research Department, Kenyatta National Hospital , Nairobi , Kenya

4. Department of Pediatrics and Department of Medicine, Baylor College of Medicine , Houston, Texas , USA

5. Department of Biostatistics, University of Washington , Seattle, Washington , USA

6. Division of Infectious Diseases, Department of Pediatrics, Emory University , Atlanta, Georgia , USA

7. Children’s Healthcare of Atlanta , Atlanta, Georgia , USA

8. Department of Pediatrics and Child Health, University of Nairobi , Nairobi , Kenya

9. Department of Reproductive Health, Kenyatta National Hospital , Nairobi , Kenya

10. Department of Epidemiology, University of Washington , Seattle, Washington , USA

11. Department of Pediatrics, University of Washington , Seattle, Washington , USA

Abstract

Abstract Cumulative 24-month Mycobacterium tuberculosis infection incidence (measured primarily by tuberculin skin test [TST]) was high among human immunodeficiency virus exposed but uninfected infants (8.7 [95% confidence interval, 6.3–11.9] per 100 person-years). Trend for decreased TST positivity among infants at trial end (12 months postenrollment) randomized to isoniazid at 6 weeks of age was not sustained through observational follow-up to 24 months of age. Clinical Trials Registration NCT02613169.

Funder

Thrasher Research Fund

National Institute of Allergy and Infectious Diseases

National Institutes of Health

National Center for Advancing Translational Sciences

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac393/44356701/ciac393.pdf

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