Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study-Reference-Cited by-同舟云学术

Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study

Published:2022-02-10 Issue:6 Volume:75 Page:1088-1091
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Liebenberg Lenine J P¹²^ORCID,Passmore Jo Ann S¹³⁴,Osman Farzana¹,Jewanraj Janine¹²,Mtshali Andile¹²,Gerardo Garcia-Lerma J⁵,Heneine Walid⁵,Holder Angela⁵,Archary Derseree¹²,Ngcapu Sinaye¹²,Sivro Aida¹²⁶,Mansoor Leila E¹⁷,Abdool Karim Quarraisha¹⁸,Abdool Karim Salim S¹⁸,McKinnon Lyle R¹⁶

Affiliation:

1. Centre for the AIDS Programme of Research in South Africa (CAPRISA) , Durban , South Africa

2. School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal , Durban , South Africa

3. Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town , Cape Town , South Africa

4. National Health Laboratory Service , Cape Town , South Africa

5. Division of HIV/AIDS Prevention, National Center for HIV/ AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

6. Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba , Canada

7. School of Nursing and Public Health, University of KwaZulu-Natal , Durban , South Africa

8. Department of Epidemiology, Columbia University , New York, New York , USA

Abstract

Abstract Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.

Funder

National Institutes of Health

DST-NRF Centre of Excellence in HIV Prevention at CAPRISA

Centre for the AIDS Programme of Research in South Africa

Contraception Research and Development

Cooperative Agreement

US Agency for International Development

US President’s Emergency Plan for AIDS Relief

South African Department of Science and Technology

Technology Innovation Agency

MACAIDS Fund

Tides Foundation

National Research Foundation (NRF) Research

European and Developing Countries Clinical Trials Partnership

Canadian Institutes of Health Research

NRF Research Career Advancement

SANTHE Path

African Academy of Sciences

Royal Society

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac115/43374544/ciac115.pdf

Reference19 articles.

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2. Topical microbicides for preventing sexually transmitted infections.;Obiero;Cochrane Database Syst Rev,2021

3. Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.;McKinnon;Nat Med,2018

4. Genital inflammation and the risk of HIV acquisition in women.;Masson;Clin Infect Dis,2015

5. Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.;Arnold;Mucosal Immunol,2016

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