High Asymptomatic Carriage With the Omicron Variant in South Africa
Author:
Garrett Nigel1, Tapley Asa23, Andriesen Jessica2, Seocharan Ishen4, Fisher Leigh H2, Bunts Lisa2, Espy Nicole2, Wallis Carole L5, Randhawa April Kaur2, Miner Maurine D2ORCID, Ketter Nzeera2, Yacovone Margaret6, Goga Ameena47, Huang Yunda28, Hural John2, Kotze Philip9, Bekker Linda Gail10, Gray Glenda E4, Corey Lawrence2, Ahmed Khatija, Badal-Faesen Sharlaa, Barnabas Shaun, Brumskine William, Comline Kim, Diacon Andreas, Dubula Thozama, Gill Katherine, Grobbelaar Coert, Innes Craig, Kassim Sheetal, Kotze Sheena, Lazarus Erica, Lombaard Johannes, Luabeya Angelique, Maboa Rebone Molobane, Mahoney Scott, Mahkaza Disebo, Malahleha Moelo, Malan Daniel, Mngadi Kathryn, Naicker Nivashnee, Naicker Vimla, Naidoo Logashvari, Nchabeleng Maphoshane, Rassool Mohammed, Spooner Elizabeth, Tempelman Hugo, Mgodi Nyaradzo, Dadabhai Sufia, Makhema Joe, Nuwagaba-Biribonwoha Harriet, Samandari Taraz, Elyanu Peter James, Chilengi Roma, Chirenje Zvavahera, McElrath Julie, Cohen Myron, Kublin James, Gilbert Peter, Peda Melissa, Andersen-Nissen Erica, Ferrari Guido, Villaran Manuel, Takalani Azwidhwi, Gildea Marianne, Nebergall Michelle, Sopher Carrie, Proulx-Burns Lori, Govender Dhevium, Sanders Lisa, Hanke Jen, Baepanye Kagisho, Roux Bert Le, Wilvich Haven, Sripathy Smitha, Margineantu Daciana, Brown Valerie, Linton Kim, Howell Haley, Noronha Bianca, Nikles Sarah, Toledano Alicia, May Jeanine, El-Khorazaty Jill, Naidoo Keshani, Takalani Azwidhwi, Khuto Kentse, Mayat Fatima, Fairall Lara, Sanne Ian,
Affiliation:
1. Centre for the AIDS Programme of Research in South Africa, University of KwaZulu–Natal , Durban , South Africa 2. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, Washington , USA 3. University of Washington School of Medicine , Seattle, Washington , USA 4. South African Medical Research Council , Cape Town , South Africa 5. Bio Analytical Research Corporation South Africa and Lancet Laboratories , Johannesburg , South Africa 6. National Institute of Allergy and Infectious Diseases , National Institutes of Health, Bethesda, Maryland , USA 7. University of Pretoria , Pretoria , South Africa and 8. Department of Global Health, University of Washington , Seattle, Washington , USA 9. Qhakaza Mbokodo Research Clinic , Ladysmith , South Africa 10. Desmond Tutu HIV Centre, University of Cape Town , Cape Town , South Africa
Abstract
Abstract
We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4 + T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.
Funder
National Institutes of Health Elma Vaccines and Immunization Foundation Bill and Melinda Gates Foundation
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Microbiology (medical)
Cited by
59 articles.
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