Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and SARS-CoV-2–Related Hospitalizations: A Statewide Report From the Minnesota Electronic Health Record Consortium

Author:

Drawz Paul E1ORCID,DeSilva Malini2,Bodurtha Peter3,Vazquez Benitez Gabriela2,Murray Anne4,Chamberlain Alanna M5,Dudley R Adams6,Waring Stephen7,Kharbanda Anupam B8,Murphy Daniel1,Muscoplat Miriam Halstead9,Melendez Victor10,Margolis Karen L2,McFarling Lynn11,Lupu Roxana12,Winkelman Tyler N A3,Johnson Steven G13

Affiliation:

1. Division of Nephrology and Hypertension, University of Minnesota Medical School , Minneapolis, Minnesota , USA

2. HealthPartners Institute , Minneapolis, Minnesota , USA

3. Health, Homelessness, and Criminal Justice Laboratory, Hennepin Healthcare Research Institute , Minneapolis, Minnesota , USA

4. Berman Center for Clinical Research, Hennepin Healthcare Research Institute , Minneapolis, Minnesota , USA

5. Department of Quantitative Health Sciences, Mayo Clinic , Rochester, Minnesota , USA

6. Center for Care Delivery and Outcomes Research, Minneapolis Veterans Affairs Medical Center , Minneapolis, Minnesota , USA

7. Essentia Institute of Rural Health , Duluth, Minnesota , USA

8. Department of Pediatric Emergency Medicine, Children’s Minnesota , Minneapolis, Minnesota , USA

9. Division of Infectious Disease, Epidemiology and Infection Control, Minnesota Department of Health , Saint Paul, Minnesota , USA

10. Allina Health , Minneapolis, Minnesota , USA

11. CentraCare , St Cloud, Minnesota , USA

12. Sanford Health , Sioux Falls, South Dakota , USA and

13. Institute for Health Informatics, University of Minnesota , Minneapolis, Minnesota , USA

Abstract

Abstract Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a 2-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the elderly and those with comorbidities.

Funder

Minnesota Department of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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