Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019

Author:

Li Yijia1ORCID,Harrison Linda J2,Chew Kara W3,Currier Judy S3,Wohl David A4,Daar Eric S5,Evering Teresa H6,Wu Ryan2,Giganti Mark2,Ritz Justin2,Javan Arzhang Cyrus7,Coombs Robert W8,Moser Carlee2,Hughes Michael D2,Eron Joseph J4,Smith Davey M9,Li Jonathan Z1

Affiliation:

1. Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA

2. Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health , Boston, Massachusetts , USA

3. Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles , Los Angeles, CA , USA

4. Department of Medicine, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina , USA

5. Lundquist Institute at Harbor–UCLA Medical Center , Los Angeles, California , USA

6. Department of Medicine, Weill Cornell Medicine , New York, New York , USA

7. National Institutes of Health , Bethesda, Maryland , USA

8. Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington , USA

9. Department of Medicine, University of California, San Diego , La Jolla, California , USA

Abstract

AbstractAcute Coronavirus Disease 2019 symptoms limit daily activities, but little is known about its association with severe acute respiratory syndrome coronavirus 2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal RNA levels and detectable plasma RNA were associated with delayed symptom improvement.Clinical Trials Registration. https://clinicaltrials.gov/ct2/show/NCT04518410.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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