Infants Receiving Very Early Antiretroviral Therapy Have High CD4 Counts in the First Year of Life

Author:

Nelson Bryan S1ORCID,Tierney Camlin1,Persaud Deborah2,Jao Jennifer34,Cotton Mark F5,Bryson Yvonne6,Coletti Anne7,Ruel Theodore D8,Spector Stephen A910,Reding Christina11,Bacon Kira11,Costello Diane12,Perlowski Charlotte7,Santos Cruz Maria Leticia13,Kosgei Josphat14,Majji Sai15,Yin Dwight E16,Jean-Philippe Patrick16,Chadwick Ellen G34,

Affiliation:

1. Center for Biostatistics in AIDS Research in the Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , USA

2. Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

3. Division of Pediatric Infectious Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA

4. Ann & Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois , USA

5. Department of Pediatrics and Child Health, Family Center for Research with Ubuntu, Stellenbosch University , Tygerberg , South Africa

6. Department of Pediatrics, University of California–Los Angeles David Geffen School of Medicine , Los Angeles, California , USA

7. Science Facilitation Department, FHI 360 , Durham, North Carolina , USA

8. Department of Pediatrics, San Francisco School of Medicine, University of California , San Francisco, California , USA

9. Department of Pediatrics, University of California San Diego School of Medicine , La Jolla, California , USA

10. Rady Children's Hospital , San Diego, California , USA

11. Frontier Science and Technology Research Foundation , Amherst, New York , USA

12. IMPAACT Laboratory Center, University of California Los Angeles , Los Angeles, California , USA

13. Infectious Diseases Department, Hospital Federal dos Servidores do Estado , Rio de Janeiro , Brazil

14. Kenya Medical Research Institute/Walter Reed Project , Kericho , Kenya

15. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, Maryland , USA

16. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland , USA

Abstract

Abstract We followed 54 infants with in utero HIV after initiating very early antiretroviral treatment. At weeks 24 and 48, ≥80% had CD4 ≥1500 cells/mm3 and CD4% ≥25%. Routine Pneumocystis jirovecii pneumonia prophylaxis in the first year of life may not be necessary for all very early treated infants. Clinical Trials Registration NCT02140255.

Funder

International Maternal Pediatric Adolescent AIDS Clinical Trials

National Institute of Allergy and Infectious Diseases

Eunice Kennedy Shriver National Institute of Child Health and Human Development

NICHD

National Institute of Mental Health

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference12 articles.

1. 1995 Revised guidelines for prophylaxis against Pneumocystis carinii pneumonia for children infected with or perinatally exposed to human immunodeficiency virus.;MMWR Recomm Rep,1995

2. Temporal trends in co-trimoxazole use among children on antiretroviral therapy and the impact of co-trimoxazole on mortality rates in children without severe immunodeficiency;Boettiger;J Pediatric Infect Dis Soc,2019

3. Trends in opportunistic infections in the pre- and post-highly active antiretroviral therapy eras among HIV-infected children in the Perinatal AIDS Collaborative Transmission Study, 1986–2004;Nesheim;Pediatrics,2007

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