Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers-Reference-Cited by-同舟云学术

Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

Published:2022-07-15 Issue:3 Volume:76 Page:e533-e536
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Sablerolles Roos S G¹²^ORCID,Rietdijk Wim J R²,Goorhuis Abraham³⁴,Postma Douwe F⁵,Visser Leo G⁶,Schmitz Katharina S⁷,Geers Daryl⁷,Bogers Susanne⁷,van Haren Eva²,Koopmans Marion P G⁷,Dalm Virgil A S H⁸,Kootstra Neeltje A⁹,Huckriede Anke L W¹⁰,Akkerman Renate¹⁰,Beukema Martin¹⁰,Lafeber Melvin¹,van Baarle Debbie¹⁰¹¹,de Vries Rory D⁷,van der Kuy P Hugo M²,GeurtsvanKessel Corine H⁷,

Affiliation:

1. Department of Internal Medicine, Erasmus Medical Center , Rotterdam , The Netherlands

2. Department of Hospital Pharmacy, Erasmus Medical Center , Rotterdam , The Netherlands

3. Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centers , Amsterdam , The Netherlands

4. Infection & Immunity, Amsterdam Public Health, University of Amsterdam , Amsterdam , The Netherlands

5. Department of Internal Medicine and Infectious Diseases, University Medical Center Groningen , Groningen , The Netherlands

6. Department of Infectious Diseases, Leiden University Medical Center , Leiden , The Netherlands

7. Department of Viroscience, Erasmus Medical Center , Rotterdam , The Netherlands

8. Department of Internal Medicine, Division of Allergy & Clinical Immunology and Department of Immunology, Erasmus Medical Center , Rotterdam , The Netherlands

9. Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Infection and Immunity Institute, University of Amsterdam , Amsterdam , The Netherlands

10. Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands

11. Center for Infectious Disease Control, National Institute for Public Health and the Environment , Bilthoven , The Netherlands

Abstract

Abstract The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2–specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

Funder

the Netherlands Organization for Health Research and Development ZonMw

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac495/44931905/ciac495.pdf

Reference9 articles.

1. Final analysis of efficacy and safety of single-dose Ad26.COV2.S;Sadoff;New Engl J Med,2022

2. Effectiveness of Ad26. COV2. S and BNT162b2 vaccines against Omicron variant in South Africa;Gray;N Engl J Med,2022

3. Immunogenicity and reactogenicity of vaccine boosters after Ad26.COV2.S Priming;Sablerolles;N Engl J Med,2022