Lower Rates of Emergency Department Visits and Hospitalizations Among Patients With Chronic Hepatitis C With Sustained Virological Response to Interferon-Free Direct-Acting Antiviral Therapy (2014

Lower Rates of Emergency Department Visits and Hospitalizations Among Patients With Chronic Hepatitis C With Sustained Virological Response to Interferon-Free Direct-Acting Antiviral Therapy (2014–2018)

Published:2022-02-11 Issue:8 Volume:75 Page:1453-1456
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Gordon Stuart C¹²,Teshale Eyasu H³,Spradling Philip R³,Moorman Anne C³,Boscarino Joseph A⁴,Schmidt Mark A⁵,Daida Yihe G⁶,Rupp Loralee B⁷,Trudeau Sheri⁸,Zhang Jiaqi⁸,Lu Mei⁸,Teshale Eyasu H,Spradling Philip R,Moorman Anne C,Xing Jian,Zhong Yuna,Gordon Stuart C,Rupp Loralee B,Trudeau Sheri,Lu Mei,Li Jia,Akkerman Nonna,Zhou Yueren,Boscarino Joseph A,Daar Zahra S,Smith Robert E,Daida Yihe G,Trinacty Connie Mah,Lai Jonathan W,Nie Sixiang,Wong Carmen P,Schmidt Mark A,Donald Judy L,

Affiliation:

1. Department of Gastroenterology and Hepatology, Henry Ford Health System , Detroit Michigan , USA

2. Wayne State University School of Medicine , Detroit Michigan , USA

3. Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

4. Department of Population Health Sciences, Geisinger Clinic , Danville, Pennsylvania , USA

5. Center for Health Research, Kaiser Permanente Northwest , Portland, Oregon , USA

6. Center for Integrated Health Care Research, Kaiser Permanente Hawaii , Honolulu, Hawaii

7. Center for Health Policy and Health Systems Research, Henry Ford Health System , Detroit Michigan , USA

8. Department of Public Health Sciences, Henry Ford Health System , Detroit Michigan , USA

Abstract

Abstract We compared rates of emergency department visits and hospitalizations between patients with hepatitis C virus who achieved sustained virological response after direct-acting antiviral therapy (case patients) and matched controls. Among 3049 pairs, case patients demonstrated lower rates of liver-related emergency department visits (P = .01) than controls; all-cause and liver-related hospitalization rates and number of hospitalized days were also lower in case patients (P < .001).

Funder

CHeCS

AbbVie

Genentech

Gilead Sciences

Janssen Pharmaceuticals,

Vertex Pharmaceuticals

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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