Monoclonal Antibodies as Long-Acting Products: What Are We Learning From Human Immunodeficiency Virus (HIV) and Coronavirus Disease 2019 (COVID-19)?

Author:

Caskey Marina1,Kuritzkes Daniel R23

Affiliation:

1. Rockefeller University , New York, New York , USA

2. Division of Infectious Diseases, Brigham and Women's Hospital , Boston, Massachusetts , USA

3. Harvard Medical School , Boston, Massachusetts , USA

Abstract

Abstract Broadly neutralizing antibodies directed against human immunodeficiency virus (HIV) offer promise as long-acting agents for prevention and treatment of HIV. Progress and challenges are discussed. Lessons may be learned from the development of monoclonal antibodies to treat and prevent COVID-19.

Funder

National Institutes of Health

Harvard University

Centers for AIDS Research

BEAT-HIV

Cure

Boston HIV Clinical Trials Unit

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference98 articles.

1. Recent progress in broadly neutralizing antibodies to HIV;Sok;Nat Immunol,2018

2. Antibodies in HIV-1 vaccine development and therapy;Klein;Science,2013

3. Broadly neutralizing antibodies against HIV-1 and concepts for application;Gruell;Curr Opin Virol,2022

4. The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection;Gray;J Virol,2011

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