Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

Author:

Kotiloglu-Karaa Esin1,Kele Beatrix2,Kulasegaran-Shylini Raghavendran2,Broad Claire E2,Owoyemi Dola2,Martin Joanne3,MacPhail Graham1,Iliodromiti Stamatina4,Riddell Anna2,Alexander Eliza2,Cutino-Moguel Teresa23ORCID

Affiliation:

1. Department of Cellular Pathology, The Royal London Hospital, Barts Health , United Kingdom

2. Division of Infection, The Royal London Hospital, Barts Health , United Kingdom

3. Blizard Institute, Centre for Genomics and Child Health, Queen Mary University , London , United Kingdom

4. Centre for Women’s Health, Institute of Population Health Sciences, Queen Mary University London , United Kingdom

Abstract

Abstract We observed an increased frequency of massive perivillous fibrin deposition (MPFD) during the second coronavirus disease 2019 (COVID-19) pandemic wave dominated by the Alpha variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MPFD associated with 100% reverse transcription polymerase chain reaction (RT-PCR) positivity for SARS-CoV-2 and detection by immunohistochemistry. The Alpha variant was identified in all placentas with MPFD that could be sequenced.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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