Doravirine Concentrations and Human Immunodeficiency Virus Type 1 RNA in the Genital Fluids of Virologically Suppressed Adults Switching to Doravirine Plus Emtricitabine/Tenofovir Alafenamide-Reference-Cited by-同舟云学术

Doravirine Concentrations and Human Immunodeficiency Virus Type 1 RNA in the Genital Fluids of Virologically Suppressed Adults Switching to Doravirine Plus Emtricitabine/Tenofovir Alafenamide

Published:2022-05-25 Issue:11 Volume:75 Page:2012-2015
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Scévola Sofía¹,Imaz Arkaitz¹,Cottrell Mackenzie L²,Niubo Jordi³,Van Horne Brian²,Tiraboschi Juan¹,Saumoy Maria¹,Morenilla Sandra¹,Soriano Irene¹,Kashuba Angela D M²,Podzamczer Daniel¹

Affiliation:

1. HIV and STI Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L’Hospitalet de Llobregat , Barcelona , Spain

2. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina , USA

3. Department of Microbiology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L’Hospitalet de Llobregat , Barcelona , Spain

Abstract

Abstract Doravirine (DOR) concentrations and HIV-1 RNA were evaluated in genital fluids from adults with HIV on stable therapy who switched to DOR + FTC/TAF. High protein-unbound DOR concentrations were observed in both seminal plasma and cervicovaginal fluid. DOR + FTC/TAF maintained viral suppression in genital fluids in all but 1 participant.

Funder

Merck Sharp & Dohme

European Regional Development Fund

University of North Carolina at Chapel Hill

Center for AIDS Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac410/44370138/ciac410.pdf

Reference20 articles.