Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study

Author:

Kamau Edwin12ORCID,Chaudhury Sidhartha3,Bolton Jessica S45,Slike Bonnie M12,Jian Ningbo124,Eller Michael A12,Eller Leigh Anne12,Ake Julie1,Robb Merlin L12,Krebs Shelly J12,Bergmann-Leitner Elke S5

Affiliation:

1. United States. Military HIV Research Program, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA

2. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California , Los Angeles, Los Angeles, California , USA

3. Center for Enabling Capabilities, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA

4. Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, Maryland , USA

5. Biologics Research and Development, Walter Reed Army Institute of Research , Silver Spring, Maryland , USA

Abstract

Abstract Human immunodeficiency virus (HIV) and malaria infection rates overlap across sub-Saharan Africa, but factors influencing their co-occurrence are unclear. In a case-control study, we investigated whether malaria exposure increases risk of type 1 (HIV-1) acquisition. Prior to seroconverting, HIV-positive cases had significantly higher malaria-associated antibodies compared to HIV-negative controls, linking malaria exposure to HIV-1 acquisition.

Funder

Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc

United States Department of Defense

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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