Comparison of Waning Neutralizing Antibody Responses Against the Omicron Variant 6 Months After Natural Severe Acute Respiratory Syndrome Coronavirus 2 Infection (With or Without Subsequent Coronavirus Disease 2019 [COVID-19] Vaccination) Versus 2-Dose COVID-19 Vaccination

Author:

Lim So Yun1,Park Soonju2,Kim Ji Yeun1,Kim Seungtaek2,Jee Youngmee2,Kim Sung-Han1ORCID

Affiliation:

1. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Republic of Korea

2. Institut Pasteur Korea , Seongnam-si, Gyeonggi-do , Republic of Korea

Abstract

Abstract Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, subsequent ChAdOx1 nCoV-19 vaccination induced similar neutralizing antibody levels against the original strain but significantly higher levels against the Omicron variant compared to those who were not vaccinated. Prior SARS-CoV-2 infection exhibited higher neutralization antibody titers than vaccination alone for both original strains and the Omicron variant.

Funder

Korea Advanced Research Program

National Research Foundation of Korea

Ministry of Science and ICT, Republic of Korea

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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