Comparative Effectiveness of mRNA and Inactivated Whole-Virus Vaccines Against Coronavirus Disease 2019 Infection and Severe Disease in Singapore

Author:

Premikha M1ORCID,Chiew Calvin J1,Wei Wycliffe E1,Leo Yee Sin23456,Ong Benjamin14,Lye David Chien2345,Lee Vernon J16,Tan Kelvin Bryan16

Affiliation:

1. Ministry of Health , Singapore

2. National Centre for Infectious Diseases , Singapore

3. Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore

4. Yong Loo Lin School of Medicine, National University of Singapore , Singapore

5. Department of Infectious Diseases, Tan Tock Seng Hospital , Singapore

6. Saw Swee Hock School of Public Health, National University of Singapore , Singapore

Abstract

Abstract Compared with individuals vaccinated with Pfizer-BioNTech/Comirnaty, recipients of Sinovac-CoronaVac and Sinopharm were 2.37 (95% CI, 2.29–2.46) and 1.62 (95% CI, 1.43–1.85) times more likely to be infected with coronavirus disease 19, respectively, while individuals vaccinated with Moderna were 0.42 (95% CI, 0.25–0.70) times less likely to develop severe disease.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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