The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland-Reference-Cited by-同舟云学术

The Effectiveness of Low Dead Space Syringes for Reducing the Risk of Hepatitis C Virus Acquisition Among People Who Inject Drugs: Findings From a National Survey in England, Wales, and Northern Ireland

Published:2022-02-20 Issue:6 Volume:75 Page:1073-1077
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Trickey Adam¹^ORCID,Croxford Sara²,Emanuel Eva²,Ijaz Samreen²,Hickman Matthew¹³,Kesten Joanna¹³⁴,Thomas Clare¹³⁴,Edmundson Claire²,Desai Monica²,Vickerman Peter¹³

Affiliation:

1. Population Health Sciences, University of Bristol , Bristol , United Kingdom

2. UK Health Security Agency , London , United Kingdom

3. NIHR Health Protection Research Unit in Behavioural Science and Evaluation at University of Bristol , Bristol , United Kingdom

4. The National Institute for Health Research Applied Research Collaboration West (NIHR ARC West) at University Hospitals Bristol and Weston NHS Foundation Trust , United Kingdom

Abstract

Abstract Syringes with attached needles (termed fixed low dead space syringes [LDSS]) retain less blood following injection than syringes with detachable needles, but evidence on them reducing blood-borne virus transmission among people who inject drugs (PWID) is lacking. Utilizing the UK Unlinked Anonymous Monitoring cross-sectional bio-behavioral surveys among PWID for 2016/18/19 (n = 1429), we showed that always using fixed LDSS was associated with 76% lower likelihood (adjusted odds ratio = 0.24, 95% confidence interval [CI]: .08–.67) of recent hepatitis C virus infection (RNA-positive and antibody-negative) among antibody-negative PWID compared to using any syringes with detachable needles.

Funder

Wellcome Trust

National Institute of Allergy and Infectious Diseases

National Institute on Drug Abuse

National Institute for Health Research Health Protection Research Units

UK Health Security Agency

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac140/43516438/ciac140.pdf

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