Affiliation:
1. Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Research Group in Cheminformatics & Nutrition , Tarragona, Spain
Abstract
Abstract
This opinion article addresses a major issue in molecular biology and drug discovery by highlighting the complications that arise from combining polyproteins and their functional products within the same database entry. This problem, exemplified by the discovery of novel inhibitors for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease, has an influence on our ability to retrieve precise data and hinders the development of targeted therapies. It also emphasizes the need for improved database practices and underscores their significance in advancing scientific research. Furthermore, it emphasizes the need of learning from the SARS-CoV-2 pandemic in order to improve global preparedness for future health crises.
Funder
Ministerio de Ciencia e Innovación
Agencia Estatal de Investigación
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Information Systems