Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study

Author:

Feikin Daniel R.12,Fu Wei13,Park Daniel E.14,Shi Qiyuan1,Higdon Melissa M.1,Baggett Henry C.56,Brooks W. Abdullah78,Deloria Knoll Maria1,Hammitt Laura L.19,Howie Stephen R. C.101112,Kotloff Karen L.13,Levine Orin S.114,Madhi Shabir A.1516,Scott J. Anthony G.917,Thea Donald M.18,Adrian Peter V.1516,Antonio Martin101920,Awori Juliet O.9,Baillie Vicky L.1516,DeLuca Andrea N.121,Driscoll Amanda J.1,Ebruke Bernard E.10,Goswami Doli7,Karron Ruth A.22,Li Mengying123,Morpeth Susan C.91724,Mwaba John2526,Mwansa James2526,Prosperi Christine1,Sawatwong Pongpun5,Sow Samba O.27,Tapia Milagritos D.13,Whistler Toni56,Zaman Khalequ7,Zeger Scott L.28,O’ Brien Katherine L.1,Murdoch David R.2930,O’Brien Katherine L.,Levine Orin S.,Knoll Maria Deloria,Feikin Daniel R.,DeLuca Andrea N.,Driscoll Amanda J.,Fancourt Nicholas,Fu Wei,Hammitt Laura L.,Higdon Melissa M.,Kagucia E. Wangeci,Karron Ruth A.,Li Mengying,Park Daniel E.,Prosperi Christine,Wu Zhenke,Zeger Scott L.,Watson Nora L.,Crawley Jane,Murdoch David R.,Brooks W. Abdullah,Endtz Hubert P.,Zaman Khalequ,Goswami Doli,Hossain Lokman,Jahan Yasmin,Ashraf Hasan,Howie Stephen R. C.,Ebruke Bernard E.,Antonio Martin,McLellan Jessica,Machuka Eunice,Shamsul Arifin,Zaman Syed M.A.,Mackenzie Grant,Scott J. Anthony G.,Awori Juliet O.,Morpeth Susan C.,Kamau Alice,Kazungu Sidi,Ominde Micah Silaba,Kotloff Karen L.,Tapia Milagritos D.,Sow Samba O.,Sylla Mamadou,Tamboura Boubou,Onwuchekwa Uma,Kourouma Nana,Toure Aliou,Madhi Shabir A.,Moore David P.,Adrian Peter V.,Baillie Vicky L.,Kuwanda Locadiah,Mudau Azwifarwi,Groome Michelle J.,Mahomed Nasreen,Baggett Henry C.,Thamthitiwat Somsak,Maloney Susan A.,Bunthi Charatdao,Rhodes Julia,Sawatwong Pongpun,Akarasewi Pasakorn,Thea Donald M.,Mwananyanda Lawrence,Chipeta James,Seidenberg Phil,Mwansa James,wa Somwe Somwe,Kwenda Geoffrey,Anderson Trevor P.,Mitchell Joanne,

Affiliation:

1. Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

2. Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

3. Department of Rheumatology, Johns Hopkins School of Medicine, Baltimore, Maryland;

4. Milken Institute School of Public Health, Department of Epidemiology and Biostatistics, George Washington University, District of Columbia;

5. Global Disease Detection Center, Thailand Ministry of Public Health–US Centers for Disease Control and Prevention Collaboration, Nonthaburi;

6. Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;

7. International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka and Matlab;

8. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

9. Kenya Medical Research Institute–Wellcome Trust Research Programme, Kilifi;

10. Medical Research Council Unit, Basse, The Gambia;

11. Department of Paediatrics, University of Auckland, and

12. Centre for International Health, University of Otago, Dunedin, New Zealand;

13. Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, Institute of Global Health, University of Maryland School of Medicine, Baltimore;

14. Bill & Melinda Gates Foundation, Seattle, Washington;

15. Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, and

16. Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases Unit, University of the Witwatersrand, Johannesburg, South Africa;

17. Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, United Kingdom;

18. Center for Global Health and Development, Boston University School of Public Health, Massachusetts;

19. Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, and

20. Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, United Kingdom;

21. Department of Epidemiology,

22. Department of International Health, Center for Immunization Research, and

23. Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

24. Microbiology Laboratory, Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand;

25. Department of Pathology and Microbiology, University Teaching Hospital, and

26. Zambia Center for Applied Health Research and Development, Lusaka;

27. Centre pour le Développement des Vaccins (CVD-Mali), Bamako;

28. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

29. Department of Pathology, University of Otago, and

30. Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference38 articles.

1. Specimen collection for the diagnosis of pediatric pneumonia;Hammitt;Clin Infect Dis,2012

2. Viral pneumonia;Ruuskanen;Lancet,2011

3. Breathing new life into pneumonia diagnostics;Murdoch;J Clin Microbiol,2009

4. Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values;Jansen;J Clin Microbiol,2011

5. Density of upper respiratory colonization with Streptococcus pneumoniae and its role in the diagnosis of pneumococcal pneumonia among children aged <5 years in the PERCH study;Baggett;Clin Infect Dis,2017

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