Long-term Therapeutic Impact of the Timing of Antiretroviral Therapy in Patients Diagnosed With Primary Human Immunodeficiency Virus Type 1 Infection

Author:

Novelli Sophie1,Lécuroux Camille2,Avettand-Fenoel Véronique3,Seng Rémonie4,Essat Asma1,Morlat Philippe5,Viard Jean-Paul6,Rouzioux Christine3,Meyer Laurence4,Goujard Cécile7

Affiliation:

1. National Institute of Health and Medical Research (INSERM), Centre for Research in Epidemiology and Population Health (CESP), Paris-Sud University, France

2. Commissariat à l'énergie atomique et aux énergies alternatives (CEA) –Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), Infectious Disease Models and Innovative Therapie (IDMIT), Institut de biologie François Jacob (IBJF), Direction de la recherche fondamentale (DRF), Fontenay-aux-Roses, France

3. Paris Descartes University, EA 7327, Sorbonne Paris Cité, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital, Virology Department, France

4. INSERM, CESP, U1018, Paris-Sud University, AP-HP, Bicêtre Hospital, Department of Public Health and Epidemiology, Le Kremlin-Bicêtre, France

5. Bordeaux University Hospital, Saint André Hospital, Department of Internal Medicine, France

6. Paris Descartes University, EA 7327, Sorbonne Paris Cité, AP-HP, Hôtel Dieu Hospital, Unit of Therapeutics in Immunology and Infectiology, France

7. INSERM, CESP, U1018, Paris-Sud University, AP-HP, Bicêtre Hospital, Department of Internal Medicine, Le Kremlin-Bicêtre, France

Funder

French National Agency for Research on AIDS and Viral Hepatitis

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference39 articles.

1. Prevention of HIV-1 infection with early antiretroviral therapy;Cohen;N Engl J Med,2011

2. Long-term antiretroviral therapy initiated during primary HIV-1 infection is key to achieving both low HIV reservoirs and normal T cell counts;Hocqueloux;J Antimicrob Chemother,2013

3. Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission;Chéret;J Antimicrob Chemother,2015

4. Short-course antiretroviral therapy in primary HIV infection;SPARTAC Trial Investigators;N Engl J Med,2013

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