Affiliation:
1. Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, Providence
2. Division of Infectious Disease, Rhode Island Hospital and Alpert Medical School of Brown University, Providence
Abstract
Abstract
Background
Spontaneous splenic rupture is an increasingly reported complication of babesiosis and has been described as a severe complication.
Methods
We performed a retrospective chart review in a high-prevalence area to identify 7 cases of babesiosis-related splenic rupture between 2014 and 2016.
Results
Splenic rupture occurred in approximately 1% of babesiosis cases. Compared to cases without splenic rupture, these patients were younger (by >10 years), healthier (most with ≤1 comorbidity), had a lower degree of parasitemia (<10%), and were less likely to have end-organ dysfunction other than their splenic involvement.
Conclusions
Younger, healthier patients may be more prone to develop splenic rupture, as splenic histiocytes engage in more robust erythrophagocytosis, leading to pathological mechanical strain and rupture.
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Microbiology (medical)
Reference20 articles.
1. Human babesiosis;Vannier;N Engl J Med,2012
2. Babesiosis, significance of spleen function illustrated by postsplenectomy course in 3 cases;Siderits;Infect Dis Clin Pract,2008
3. Case report: spontaneous splenic rupture during acute parasitemia of Babesia microti;Froberg;Ann Clin Lab Sci,2008
4. Atraumatic splenic rupture from Babesia: a disease of the otherwise healthy patient;Farber;Ticks Tick Borne Dis,2015
5. Spontaneous splenic rupture caused by Babesia microti infection;Kuwayama;Clin Infect Dis,2008
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献