Safety of Antiretroviral Exposure During Pregnancy: Opportunities to Close Data Gaps

Author:

Short William R1ORCID,Miller Emily S2,Simone Joanne3,Statton Anne4,Finocchario-Kessler Sarah5,Lampe Margaret6

Affiliation:

1. Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania , USA

2. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Alpert Medical School of Brown University , Providence, Rhode Island , USA

3. Francois-Xavier Bagnoud Center, School of Nursing, Rutgers, The State University of New Jersey , Newark, New Jersey , USA

4. Mother and Child Alliance , Chicago, Illinois , USA

5. Department of Family Medicine & Community Health, University of Kansas Medical Center , Kansas City, Kansas , USA

6. Division of HIV Prevention, National Center for HV, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

Abstract

Abstract Pregnant persons with chronic health conditions often require pharmacotherapy to remain healthy. The Antiretroviral Pregnancy Registry is a prospective, international, voluntary, and exposure registry that collects information on antiretroviral (ARV) exposure; however, a minority of providers use the registry, leaving critical gaps to guide prescribing in this population. The Task Force for the Elimination of Perinatal HIV Transmission in the United States, funded by the Centers for Disease Control and Prevention, has identified the monitoring of ARV safety as a paramount concern in the ongoing mission to eliminate perinatal human immunodeficiency virus (HIV) transmission. As active members of this task force, we urge all healthcare providers who care for pregnant individuals to prioritize reporting all ARV exposures to the registry.

Publisher

Oxford University Press (OUP)

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3. Importance of prospective studies in pregnant and breastfeeding women living with human immunodeficiency virus;Colbers;Clin Infect Dis,2019

4. Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents);Brent;Pediatrics,2004

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