Genomic Analysis of Group B <i>Streptococcus</i> Carriage Isolates From Botswana Reveals Distinct Local Epidemiology and Identifies Novel Strains-Reference-Cited by-同舟云学术

Genomic Analysis of Group B Streptococcus Carriage Isolates From Botswana Reveals Distinct Local Epidemiology and Identifies Novel Strains

Published:2023-09-30 Issue:10 Volume:10 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Hanze Villavicencio Karen L¹²,Job Megan J³,Burghard Anne Claire³⁴,Taffet Allison³,Banda Francis M⁵,Vurayai Moses⁶,Mokomane Margaret⁶,Arscott-Mills Tonya⁵⁷⁸,Mazhani Tiny⁵,Nchingane Seeletso⁹,Thomas Brady¹⁰,Steenhoff Andrew P¹²⁵⁷⁸,Ratner Adam J³¹¹^ORCID

Affiliation:

1. Division of Infectious Diseases, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania , USA

2. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA

3. Department of Pediatrics, NewYork University Grossman School of Medicine , New York, New York, USA

4. Renaissance School of Medicine, Stony Brook University , Stony Brook, NewYork, USA

5. Department of Pediatrics & Adolescent Health, Faculty of Medicine, University of Botswana , Gaborone , Botswana

6. School of Allied Health Professionals, Faculty of Health Sciences, University of Botswana , Gaborone , Botswana

7. Botswana-UPenn Partnership , Faculty of Health Sciences, University of Botswana, Gaborone , Botswana

8. Global Health Center, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania , USA

9. Department of Pediatrics, Princess Marina Hospital , Gaborone , Botswana

10. Department of Pediatrics, Stead Family Children's Hospital, University of Iowa , Iowa City, Iowa , USA

11. Department of Microbiology, NewYork University Grossman School of Medicine , New York, New York, USA

Abstract

Abstract In pregnant people colonized with group B Streptococcus (GBS) in Botswana, we report the presence/expansion of sequence types 223 and 109, a low rate of erythromycin resistance, and 3 novel sequence types. These data highlight the importance of local epidemiologic studies of GBS, a significant source of neonatal disease.

Funder

Melissa Ketunuti Basselier Endowment

Children's Hospital of Philadelphia

Penn Center for AIDS Research

National Institutes of Health

Pediatric Infectious Diseases Society

Department of Pediatrics, New York University Grossman School of Medicine

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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