Leptospirosis Followed by Kawasaki-Like Disease: Case Report From an Adult Swiss Patient and Review of the Literature

Author:

Baerlocher Severin1,Helfenstein Seth2,Mahr Alfred3,Crippa Selina4,Garcia Boy Regine5,Kahlert Christian R26,Yurttas Timur7,Hatz Christoph278,Kohler Philipp2ORCID

Affiliation:

1. Department of Internal Medicine, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland

2. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland

3. Department of Rheumatology, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland

4. Department of Internal Medicine, Regional Hospital of Grabs, St. Gallen, Switzerland

5. Zentrum für Labormedizin, St. Gallen, Switzerland

6. Children’s Hospital of Eastern Switzerland, Infectious Diseases and Hospital Epidemiology, St. Gallen, Switzerland

7. University of Basel, Basel, Switzerland

8. Department of Medicine, Swiss TPH, Basel, Switzerland

Abstract

Abstract Kawasaki disease (KD) is a vasculitis that mostly occurs in children, but rare cases in adults have been reported. We describe the case of a 43-year-old Swiss male who developed symptoms compatible with KD 7 weeks after leptospirosis, which was presumably acquired after swimming in a creek in the Swiss Alps. We performed a literature review and identified 10 other cases (all in children), in which Kawasaki-like disease was diagnosed in the context of leptospirosis. Outcome was favourable in most cases, including our patient. This exceptional case demonstrates both the possibility of autochthonous cases of leptospirosis in Switzerland as well as a possible association of leptospirosis with Kawasaki-like disease.

Funder

Swiss National Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference33 articles.

1. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association;Newburger;Circulation,2004

2. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association;McCrindle Brian;Circulation,2017

3. A case of Kawasaki disease with concomitant leptospirosis;Foo;Glob Pediatr Health,2017

4. Leptospirosis mimicking MLNS;Humphry;J Pediatr,1977

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