Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak-Reference-Cited by-同舟云学术

Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak

Published:2020-01-21 Issue:2 Volume:7 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Falcone Marco¹,Tiseo Giusy¹,Antonelli Alberto²^ORCID,Giordano Cesira³,Di Pilato Vincenzo²,Bertolucci Pietro⁴,Parisio Eva Maria⁵,Leonildi Alessandro⁴,Aiezza Noemi²,Baccani Ilaria²,Tagliaferri Enrico⁶,Righi Lorenzo⁷,Forni Silvia⁸,Sani Spartaco⁹,Mechi Maria Teresa⁷,Pieralli Filippo¹⁰,Barnini Simona³,Rossolini Gian Maria²¹¹,Menichetti Francesco¹

Affiliation:

1. Infectious Disease Unit, Azienda Ospedaliera Universitaria Pisana, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

2. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

3. Microbiology Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy

4. Faculty of Medicine, University of Pisa, Pisa, Italy

5. Operative Unit of Chemical-Clinical and Microbiological Analysis, San Luca Hospital, Lucca, Italy

6. Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy

7. Quality of Care and Clinical Networks, Tuscany Region, Italy

8. Agenzia Regionale di Sanità della Toscana, Florence, Italy

9. Infectious Disease Unit, Livorno Hospital, Livorno, Italy

10. Intermediate Care Unit, Florence Careggi University Hospital, Florence, Italy

11. Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy

Abstract

Abstract Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa011/31895258/ofaa011.pdf

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