Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease-Reference-Cited by-同舟云学术

Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease

Published:2022-06-06 Issue:7 Volume:9 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Khan Farhan¹²,Allehebi Ziyad¹²,Shabi Yahya¹²,Davis Ian¹²,LeBlanc Jason¹²,Lindsay Robbin³,Hatchette Todd¹²^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, Queen Elizabeth II Health Science Centre , Halifax, Nova Scotia , Canada

2. Department of Pathology, Dalhousie University , Halifax, Nova Scotia , Canada

3. Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory (NML), Public Health Agency of Canada (PHAC) , Winnipeg, Manitoba , Canada

Abstract

Abstract The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early infection compared with the standard 2-tier algorithm while retaining high specificity in a region with a high incidence of LD.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofac272/43964302/ofac272.pdf

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