Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents-Reference-Cited by-同舟云学术

Low Adherence Achieves High HCV Cure Rates Among People Who Inject Drugs Treated With Direct-Acting Antiviral Agents

Published:2020-08-26 Issue:10 Volume:7 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Norton Brianna L¹^ORCID,Akiyama Matthew J¹,Agyemang Linda¹,Heo Moonseong²,Pericot-Valverde Irene-³,Litwin Alain H³⁴⁵

Affiliation:

1. Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA

2. Department of Public Health Sciences, Clemson University, Clemson, South Carolina, USA

3. Department of Medicine, University of South Carolina School of Medicine – Greenville, Greenville, South Carolina, USA

4. Clemson University School of Health Research, Clemson, South Carolina, USA

5. Prisma Health, Greenville, South Carolina, USA

Abstract

Abstract We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa377/33683287/ofaa377.pdf

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