Delayed Relapse of Paracoccidioidomycosis in the Central Nervous System: A Case Report

Author:

Rahman Rifat1,Davies Leela234,Mohareb Amir M234,Peçanha-Pietrobom Paula M5ORCID,Patel Nirav J6,Solomon Isaac H7,Meredith David M7,Tsai Harrison K7,Guenette Jeffrey P8,Bhattacharyya Shamik9,Urday Sebastian9,Velásquez Gustavo E21011ORCID

Affiliation:

1. Harvard Medical School, Boston, Massachusetts, USA

2. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA

3. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

4. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

5. Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil

6. Department of Neurosurgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA

7. Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

8. Division of Neuroradiology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

9. Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

10. Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA

11. Division of Global Health Equity, Brigham and Women’s Hospital, Boston, Massachusetts, USA

Abstract

Abstract Paracoccidioidomycosis is a dimorphic fungal infection endemic in Latin America. We report a patient with a history of pulmonary paracoccidioidomycosis who presented with relapsed disease in the central nervous system 4 years after initial treatment. We review current treatment strategies for paracoccidioidomycosis and neuroparacoccidioidomycosis.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Ronda Stryker and William Johnston

Fellowship in Global Health and Social Medicine

Fellowship at Harvard Medical School

Burke Global

Harvard Global Health Institute

Harvard University Center for AIDS Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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