Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B-Reference-Cited by-同舟云学术

Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B

Published:2024-07-18 Issue:8 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Pechacek Joseph¹,Schmitt Monica M¹,Ferrè Elise M N¹,Webb Taura¹,Goldberg Joel²,Pathan Sabina²,Banerjee Camellia²,Barber Princess¹,DiMaggio Thomas¹,Quinn Anne²,Matkovits Theresa³,Castelo-Soccio Leslie⁴,Nussenblatt Veronique⁵,Lionakis Michail S¹^ORCID

Affiliation:

1. Fungal Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

2. Intramural Clinical Management and Operations Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

3. Matinas Biopharma Nanotechnologies , Bedminster, New Jersey , USA

4. Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland , USA

5. Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

Abstract

Abstract Prototheca wickerhamii is a rare cause of cutaneous and systemic infection that requires long treatment courses with potentially toxic medications. We describe a patient with cutaneous protothecosis refractory to triazole monotherapy who experienced clinical and radiographic improvement with the novel oral lipid nanocrystal formulation of amphotericin B without experiencing toxicity.

Funder

Division of Intramural Research

National Institute of Allergy and Infectious Diseases

National Institutes of Health

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae428/58584103/ofae428.pdf

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4. Protothecosis;Kantrow;Dermatol Clin,2003

5. Protothecosis;Mayorga;Clin Dermatol,2012

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