Impact of Age and Symptom Development on SARS-CoV-2 Transmission in Households With Children—Maryland, New York, and Utah, August 2020–October 2021
Author:
Sumner Kelsey M12ORCID, Karron Ruth A3, Stockwell Melissa S45, Dawood Fatimah S1, Stanford Joseph B6, Mellis Alexandra1, Hacker Emily6, Thind Priyam4, Castro Maria Julia E4, Harris John Paul4, Deloria Knoll Maria7, Schappell Elizabeth3, Hetrich Marissa K7, Duque Jazmin8, Jeddy Zuha8, Altunkaynak Kim8, Poe Brandon8, Meece Jennifer9, Stefanski Elisha9, Tong Suxiang1, Lee Justin S1, Dixon Ashton1, Veguilla Vic1, Rolfes Melissa A1, Porucznik Christina A6, Bentz Meghan L, Burgin Alex, Burroughs Mark, Davis Morgan L, Joseph C Madden, Nobles Sarah, Padilla Jasmine, Sheth Mili, Daugherty Michael, Li Yan, Kelleher Anna, Tao Ying, Zhang Jing, Lynch Brian, Retchless Adam, Uehara Anna, Ng Han Jia, Council-DiBitetto Christine, Ghasri Tina, Gormley Amanda, Gatto Milena, Jordan Maria, Loehr Karen, Morsell Jason, Oliva Jennifer, Mateo Jocelyn San, Herbert Kristi, Smith Khadija, Wanionek Kimberli, Weadon Cathleen, Woods Suzanne,
Affiliation:
1. Centers for Disease Control and Prevention COVID-19 Response , Atlanta, Georgia , USA 2. Epidemic Intelligence Service, Centers for Disease Control and Prevention , Atlanta, Georgia , USA 3. Center for Immunization Research, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland , USA 4. Division of Child and Adolescent Health, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center , New York, New York , USA 5. Department of Population and Family Health, Mailman School of Public Health, Columbia University Irving Medical Center , New York, New York , USA 6. Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine , Salt Lake City, Utah , USA 7. International Vaccine Access Center, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland , USA 8. Abt Associates , Cambridge, Massachusetts , USA 9. Marshfield Clinic Research Institute , Marshfield, Wisconsin , USA
Abstract
Abstract
Background
Households are common places for spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated factors associated with household transmission and acquisition of SARS-CoV-2.
Methods
Households with children age <18 years were enrolled into prospective, longitudinal cohorts and followed from August 2020 to August 2021 in Utah, September 2020 to August 2021 in New York City, and November 2020 to October 2021 in Maryland. Participants self-collected nasal swabs weekly and with onset of acute illness. Swabs were tested for SARS-CoV-2 using reverse transcription polymerase chain reaction. We assessed factors associated with SARS-CoV-2 acquisition using a multilevel logistic regression adjusted for household size and clustering and SARS-CoV-2 transmission using a logistic regression adjusted for household size.
Results
Among 2053 people (513 households) enrolled, 180 people (8.8%; in 76 households) tested positive for SARS-CoV-2. Compared with children age <12 years, the odds of acquiring infection were lower for adults age ≥18 years (adjusted odds ratio [aOR], 0.34; 95% CI, 0.14–0.87); however, this may reflect vaccination status, which protected against SARS-CoV-2 acquisition (aOR, 0.17; 95% CI, 0.03–0.91). The odds of onward transmission were similar between symptomatic and asymptomatic primary cases (aOR, 1.00; 95% CI, 0.35–2.93) and did not differ by age (12–17 years vs <12 years: aOR, 1.08; 95% CI, 0.20–5.62; ≥18 years vs <12 years: aOR, 1.70; 95% CI, 0.52–5.83).
Conclusions
Adults had lower odds of acquiring SARS-CoV-2 compared with children, but this association might be influenced by coronavirus disease 2019 (COVID-19) vaccination, which was primarily available for adults and protective against infection. In contrast, all ages, regardless of symptoms and COVID-19 vaccination, had similar odds of transmitting SARS-CoV-2. Our findings underscore the importance of SARS-CoV-2 mitigation measures for persons of all ages.
Funder
US Centers for Disease Control and Prevention
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
3 articles.
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