Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol-Reference-Cited by-同舟云学术

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol

Published:2020-05-01 Issue:5 Volume:7 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Dagher Michael¹,Ruffin Felicia¹,Marshall Steven²³⁴⁵,Taracila Magdalena²³⁴⁵,Bonomo Robert A²³⁴⁵,Reilly Rachel⁶,Fowler Vance G¹,Thaden Joshua T¹

Affiliation:

1. Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA

2. Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

3. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

4. Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

5. United States of America CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA

6. Department of Orthopedic Surgery, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

Abstract Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to extensively drug-resistant Acinetobacter baumannii. Bacterial whole-genome sequencing identified the strain and antibiotic resistance determinants.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa150/33172938/ofaa150.pdf

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