Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study
Author:
Chandna Arjun12ORCID, Mahajan Raman3, Gautam Priyanka4, Mwandigha Lazaro5, Abhilash Kundavaram PP, Balamugesh T, Burza Sakib, Bhattacharjee Atanu, Bhusan Divendu, Chandna Arjun, Cheung Arthur T L, David Thambu, Day Nicholas, Dayanand Divya, Dittrich Sabine, Dondorp Arjen, Gautam Priyanka, Geevar Tulasi, George Biju, Ghattamaneni Srinivasa R, Gunasekaran Karthik, Gupta Richa, Hansdak Samuel G, Hussain Samreen, Iyadurai Ramya, Jimenez Carolina, Karthik Rajiv, Karthikeyan Rohini, Kazmi Sharwar, Koshiaris Constantinos, Kumar Pragya, Kumar Sanjeev, Kumar Shiril, Kumar Vikash, Kundu Debasree, Lakshmanan Ankita, Lubell Yoel, Mahajan Raman, Manesh Abi, Menggred Chonticha, Moorthy Mahesh, Mwandigha Lazaro, Osborn Jennifer, Richard-Greenblatt Melissa, Sathyendra Sowmya, Sebastian Merylin, Sharma Sadhana, Singh Veena K, Singh Vikash K, Smith Christopher, Suri Javvad, Suzuki Shuichi, Tubprasert Jaruwan, Turner Paul, Varghese George, Villanueva Annavi M G, Waithira Naomi, Zachariah Anand, Kumar Pragya6, Varghese George M4, Koshiaris Constantinos5, Lubell Yoel27, Burza Sakib38,
Affiliation:
1. Cambodia Oxford Medical Research Unit, Angkor Hospital for Children , Siem Reap , Cambodia 2. Centre for Tropical Medicine and Global Health, University of Oxford , Oxford , United Kingdom 3. Médecins Sans Frontières , New Delhi , India 4. Department of Infectious Diseases, Christian Medical College , Vellore , India 5. Nuffield Department of Primary Care Health Sciences, University of Oxford , Oxford , United Kingdom 6. Department of Community and Family Medicine, All India Institute of Medical Sciences , Patna , India 7. Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University , Bangkok , Thailand 8. Department of Clinical Research, London School of Hygiene and Tropical Medicine , London , United Kingdom
Abstract
Abstract
Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)–1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.
Funder
India Wellcome Trust Royal Society
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Reference24 articles.
1. Oxygen supplies and COVID-19 mortality in Africa;Nakkazi;Lancet Respir Med,2021 2. Managing ICU surge during the COVID-19 crisis: rapid guidelines;Aziz;Intensive Care Med,2020 3. sTREM-1 predicts mortality in hospitalized patients with infection in a tropical, middle-income country;Wright;BMC Med,2020 4. Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding;Moxon;J Thromb Haemost,2015
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|