Genomic Surveillance of Salmonella Paratyphi A: Neglected No More?

Author:

Hooda Yogesh1ORCID,Tanmoy Arif Mohammad1ORCID,Saha Samir K12ORCID,Saha Senjuti1ORCID

Affiliation:

1. Child Health Research Foundation , Dhaka , Bangladesh

2. Department of Microbiology, Bangladesh Shishu Hospital and Institute , Dhaka , Bangladesh

Abstract

Abstract Salmonella enterica serovar Paratyphi A, the causative agent of paratyphoid fever, is a neglected tropical disease with a high burden and mortality in low- and middle-income countries. Limited information is available regarding its genomic diversity, especially from South Asian countries that are collectively responsible for >80% of all paratyphoid cases. At the 2021 International Conference on Typhoid and Other Salmonelloses, researchers from the around the globe presented their work on Salmonella Paratyphi A genomics. Presentations described recent genomic data from South Asia and the development of Paratype, an open-access single-nucleotide polymorphism–based genotyping scheme, to segregate Salmonella Paratyphi A genomes in a systematic and sustainable manner. In this review, we attempt to summarize the progress made thus far on Salmonella Paratyphi A genomics and discuss the questions that remain to better understand the pathogen and develop interventions to fight it.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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