Effectiveness of the Original Monovalent Coronavirus Disease 2019 Vaccines in Preventing Emergency Department or Urgent Care Encounters and Hospitalizations Among Adults With Disabilities: VISION Network, June 2021-September 2022

Author:

Patel Palak1ORCID,Schrader Kristin E2,Rice Catherine E3,Rowley Elizabeth2,Cree Robyn A3,DeSilva Malini B4,Embi Peter J5,Gaglani Manjusha67ORCID,Grannis Shaun J89,Ong Toan C10,Stenehjem Edward11,Naleway Allison L12,Ball Sarah2,Natarajan Karthik1314ORCID,Klein Nicola P15ORCID,Adams Katherine1,Kharbanda Anupam16,Ray Caitlin1,Link-Gelles Ruth17ORCID,Tenforde Mark W1

Affiliation:

1. Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

2. Department of Clinical Research, Westat , Rockville, Maryland , USA

3. Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

4. Department of Research, Health Partners Institute , Minneapolis, Minnesota , USA

5. Department of Biomedical Informatics, Vanderbilt University Medical Center , Nashville, Tennessee , USA

6. Section of Pediatric Infectious Diseases, Department of Pediatrics, Baylor Scott & White Health , Temple, Texas , USA

7. Department of Medical Education, Texas A&M University College of Medicine , Temple, Texas , USA

8. Center for Biomedical Informatics, Regenstrief Institute , Indianapolis, Indiana , USA

9. School of Medicine, Indiana University , Indianapolis, Indiana , USA

10. School of Medicine, University of Colorado Anschutz Medical Campus , Aurora, Colorado , USA

11. Division of Infectious Diseases and Clinical Epidemiology, Intermountain Healthcare , Salt Lake City, Utah , USA

12. Department of Science Programs, Kaiser Permanente Center for Health Research , Portland, Oregon , USA

13. Department of Biomedical Informatics, Columbia University Irving Medical Center , NewYork, New York, USA

14. Medical Informatics Services, NewYork-Presbyterian Hospital , NewYork, New York, USA

15. Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research , Oakland, California , USA

16. Department of Emergency Medicine, Children’s Minnesota , Minneapolis, Minnesota , USA

17. Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

Abstract

Abstract Adults with disabilities are at increased risk for severe coronavirus disease 2019 (COVID-19). Using data across 9 states during Delta- and Omicron-predominant periods (June 2021–September 2022), we evaluated the effectiveness of the original monovalent COVID-19 messenger RNA vaccines among 521 206 emergency department/urgent care encounters (11 471 [2%] in patients with a documented disability) and 139 548 hospitalizations (16 569 [12%] in patients with a disability) for laboratory-confirmed COVID-19 illness in adults (aged ≥18 years). Across variant periods and for the primary series or booster doses, vaccine effectiveness was similar in those with and those without a disability. These findings highlight the importance of adults with disabilities staying up to date with COVID-19 vaccinations.

Funder

Baylor Scott & White Health

Columbia University Irving Medical Center

HealthPartners

Intermountain Healthcare

Kaiser Permanente Center for Health Research

Regenstrief Institute

University of Colorado

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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