Bictegravir-Based Antiretroviral Therapy-Associated Accelerated Hyperglycemia and Diabetes Mellitus

Author:

Nolan Nathanial S1ORCID,Adamson Samantha2,Reeds Dominic3,O’Halloran Jane A1

Affiliation:

1. Department of Medicine, Division of Infectious Diseases, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA

2. Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA

3. Department of Medicine, Center for Human Nutrition, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA

Abstract

Abstract Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility of adverse metabolic effects of these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months of being switched to bictegravir-based ART.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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