Hepatitis C Virus Reinfection in People With HIV in Taiwan After Achieving Sustained Virologic Response With Antiviral Treatment: The RECUR Study

Author:

Liu Chen-Hua123ORCID,Sun Hsin-Yun1ORCID,Peng Cheng-Yuan45ORCID,Hsieh Szu-Min1ORCID,Yang Sheng-Shun678ORCID,Kao Wei-Yu91011ORCID,Shih Yu-Lueng12,Lin Chih-Lin13ORCID,Liu Chun-Jen1214ORCID,Sheng Wang-Hui1ORCID,Lo Yi-Chun15ORCID,Liu Wen-Chun1,Wu Jo-Hsuan16ORCID,Su Tung-Hung12ORCID,Tseng Tai-Chung1217ORCID,Chen Pei-Jer1214ORCID,Hung Chien-Ching118ORCID,Kao Jia-Horng1217ORCID

Affiliation:

1. Department of Internal Medicine, National Taiwan University Hospital , Taipei , Taiwan

2. Hepatitis Research Center, National Taiwan University Hospital , Taipei , Taiwan

3. Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch , Yunlin , Taiwan

4. Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital , Taichung , Taiwan

5. School of Medicine, China Medical University , Taichung , Taiwan

6. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital , Taichung , Taiwan

7. School of Medicine, Chung Shan Medical University , Taichung , Taiwan

8. Institute of Biomedical Sciences, National Chung Hsing University , Taichung , Taiwan

9. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital , Taipei , Taiwan

10. School of Medicine, Taipei Medical University College of Medicine , Taipei , Taiwan

11. Graduate Institute of Clinical Medicine, Taipei Medical University College of Medicine , Taipei , Taiwan

12. Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan

13. Department of Gastroenterology, Taipei City Hospital, Ren-Ai Branch , Taipei , Taiwan

14. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine , Taipei , Taiwan

15. Centers for Disease Control , Taipei , Taiwan

16. Hamilton Glaucoma Center, Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California , San Diego, California , USA

17. Department of Medical Research, National Taiwan University Hospital , Taipei , Taiwan

18. Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine , Taipei , Taiwan

Abstract

Abstract Background Data on hepatitis C virus (HCV) reinfection in East Asian people with HIV after treatment-induced sustained virologic response (SVR) are limited. Methods HIV/HCV-coinfected patients in Taiwan who achieved SVR12 with interferon (IFN) or direct-acting antivirals (DAAs) between 2005 and 2021 underwent HCV RNA measurements at SVR24 and then biannually. HCV reinfection was defined as the detection of different HCV strains beyond SVR12. HIV-negative, low-risk individuals with SVR12 served as reference patients. Crude reinfection rates and secular trends were assessed. Multivariate Cox regression analysis was performed to identify baseline factors associated with HCV reinfection. Results A total of 216 HIV-positive and 1589 reference patients were recruited, with median follow-up durations of 3.0 and 6.0 years, respectively. During a total of 772 person-years of follow-up (PYFU), the HCV reinfection rate in HIV-positive patients was 4.02 per 100 PYFU (95% CI, 2.85–5.65), while the HCV reinfection rate in reference patients was 0.14 per 100 PYFU (95% CI, 0.09–0.23) during 10 862 PYFU. HIV-positive patients had a higher risk of HCV reinfection than reference patients (hazard ratio [HR], 17.63; 95% CI, 7.10–43.80; P < .001). No baseline factors were predictive of HCV reinfection in HIV-positive patients. The incidence of HCV reinfection in HIV-positive patients increased after 2015, when DAAs were made available in Taiwan. Conclusions The risk of HCV reinfection remains high in HIV/HCV-coinfected patients with treatment-induced SVR12. In addition to mass screening and treatment scale-up, strategies to reduce reinfection are needed for HCV microelimination in HIV-positive patients in Taiwan.

Funder

Ministry of Science and Technology, Taiwan

National Taiwan University Hospital

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference43 articles.

1. Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis;Platt;Lancet Infect Dis,2016

2. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study;Polaris Observatory HCV Collaborators;Lancet Gastroenterol Hepatol,2017

3. HIV, age, and the severity of hepatitis C virus-related liver disease: a cohort study;Kirk;Ann Intern Med,2013

4. Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study;Lo;Ann Intern Med,2014

5. Relationship of liver disease stage and antiviral therapy with liver-related events and death in adults coinfected with HIV/HCV;Limketkai;JAMA,2012

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3