Crushing and Splitting Direct-Acting Antivirals for Hepatitis C Virus Treatment: A Case Series and Literature Review

Author:

Whelchel Kristen1ORCID,Zuckerman Autumn D1ORCID,Koren David E2ORCID,Derrick Caroline3,Bouchard Jeannette4ORCID,Chastain Cody A5ORCID

Affiliation:

1. Specialty Pharmacy Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Department of Pharmacy Services, Temple University Health System, Philadelphia, Pennsylvania, USA

3. Department of Infectious Disease, University of South Carolina, Columbia, South Carolina, USA

4. Department of Pharmacy, University of South Carolina, Columbia, South Carolina, USA

5. Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Abstract Limited data exist regarding the use of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) in patients who are unable to swallow tablets. This case series describes HCV treatment in patients requiring tablet manipulation, providing evidence for safety and effectiveness of HCV DAA tablet manipulation.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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