Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
Author:
Griessbach Alexandra1ORCID, Chammartin Frédérique1, Abela Irene A23, Amico Patrizia4, Stoeckle Marcel P5, Eichenberger Anna L6, Hasse Barbara3, Braun Dominique L23, Schuurmans Macé M7, Müller Thomas F8, Tamm Michael9, Audigé Annette2, Mueller Nicolas J3, Rauch Andri6, Günthard Huldrych F23, Koller Michael T4, Trkola Alexandra2, Epp Selina2, Amstutz Alain1, Schönenberger Christof M1, Taji Heravi Ala1, Kusejko Katharina23ORCID, Bucher Heiner C1, Briel Matthias110ORCID, Speich Benjamin1ORCID, Abela Irene, Aebi-Popp Karoline, Anagnostopoulos Alexia, Battegay Manuel, Bernasconi Enos, Braun Dominique Laurent, Bucher Heiner, Calmy Alexandra, Cavassini Matthias, Ciuffi Angela, Dollenmaier Günter, Egger Matthias, Elzi Luigia, Fehr Jan, Fellay Jacques, Furrer Hansjakob, Fux Christoph, Günthard Huldrych, Hachfeld Anna, Haerry David, Hasse Barbara, Hirsch Hans, Hoffmann Matthias, Hösli Irene, Huber Michael, Jackson-Perry David, Kahlert Christian, Kaiser Laurent, Keiser Olivia, Klimkait Thomas, Kouyos Roger Dimitri, Kovari Helen, Kusejko Katharina, Labhardt Niklaus, Leuzinger Karoline, Tejada Begona Martinez de, Marzolini Catia, Metzner Karin J, Müller Nicolas, Nemeth Johannes, Nicca Dunja, Notter Julia, Paioni Paolo, Pantaleo Giuseppe, Perreau Matthieu, Rauch Andri, Salazar-Vizcaya Luisa, Schmid Patrick, Speck Roberto, Stöckle Marcel, Tarr Philip, Trkola Alexandra, Wandeler Gilles, Weisser Maja, Yerly Sabine, Amico Patrizia, Aubert John-David, Banz Vanessa, Beckmann Sonja, Beldi Guido, Berger Christoph, Berishvili Ekaterine, Berzigotti Annalisa, Binet Isabelle, Bochud Pierre-Yves, Branca Sanda, Bucher Heiner, Catana Emmanuelle, Cairoli Anne, Chalandon Yves, De Geest Sabina, De Rougemont Olivier, De Seigneux Sophie, Dickenmann Michael, Dreifuss Joëlle Lynn, Duchosal Michel, Fehr Thomas, Ferrari-Lacraz Sylvie, Garzoni Christian, Golshayan Déla, Goossens Nicolas, Haidar Fadi, Halter Jörg, Heim Dominik, Hess Christoph, Hillinger Sven, Hirsch Hans H., Hirt Patricia, Hoessly Linard, Hofbauer Günther, Huynh-Do Uyen, Immer Franz, Koller Michael, Laesser Bettina, Lamoth Frédéric, Lehmann Roger, Leichtle Alexander, Manuel Oriol, Marti Hans-Peter, Martinelli Michele, McLin Valérie, Mellac Katell, Merçay Aurélia, Mettler Karin, Mueller Nicolas J., Müller-Arndt Ulrike, Müllhaupt Beat, Nägeli Mirjam, Oldani Graziano, Pascual Manuel, Passweg Jakob, Pazeller Rosemarie, Posfay-Barbe Klara, Rick Juliane, Rosselet Anne, Rossi Simona, Rothlin Silvia, Ruschitzka Frank, Schachtner Thomas, Schaub Stefan, Scherrer Alexandra, Schnyder Aurelia, Schuurmans Macé, Schwab Simon, Sengstag Thierry, Simonetta Federico, Stampf Susanne, Steiger Jürg, Stirnimann Guido, Stürzinger Ueli, Van Delden Christian, Venetz Jean-Pierre, Villard Jean, Vionnet Julien, Wick Madeleine, Wilhelm Markus, Yerly Patrick,
Affiliation:
1. Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel , Basel , Switzerland 2. Institute of Medical Virology, University of Zurich , Zurich , Switzerland 3. Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich , Zurich , Switzerland 4. Clinic for Transplantation Immunology and Nephrology, University Hospital Basel , Basel , Switzerland 5. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel , Basel , Switzerland 6. Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern , Bern , Switzerland 7. Division of Pulmonology, University Hospital Zurich , Zurich , Switzerland 8. Nephrology Clinic, University Hospital Zurich , Zurich , Switzerland 9. Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel , Basel , Switzerland 10. Department of Health Research Methods, Evidence, and Impact, McMaster University , Hamilton , Canada
Abstract
AbstractExtension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%–98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%–100.0%]) in individuals with different levels of immunosuppression (difference, −2.8% [95% CI, −6.8% to 1.3%]).
Funder
Moderna Swiss National Science Foundation University of Zurich Foundation Promedica Foundation Research Foundation of the University of Basel
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
7 articles.
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