<i>Schistosoma mansoni</i> Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract-Reference-Cited by-同舟云学术

Schistosoma mansoni Infection Is Associated With Increased Monocytes and Fewer Natural Killer T Cells in the Female Genital Tract

Published:2022-12-01 Issue:12 Volume:9 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Kingery Justin R¹²,Chalem Andrea¹³,Mukerebe Crispin⁴,Shigella Peter S⁴,Miyaye Donald⁴,Magawa Ruth G⁴,Ward Maureen¹,Kalluvya Samuel E⁵,McCormick Jason⁶,Maganga Jane K⁴⁷,Colombe Soledad⁸,Aristide Christine¹,Corstjens Paul L A M⁹,Lee Myung Hee¹,Changalucha John M⁷,Downs Jennifer A¹⁵^ORCID

Affiliation:

1. Center for Global Health, Department of Medicine, Weill Cornell Medicine , New York, New York , USA

2. Department of Medicine, University of Louisville , Louisville, Kentucky , USA

3. Department of Epidemiology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina , USA

4. National Institute for Medical Research , Mwanza , Tanzania

5. Department of Medicine, Weill Bugando School of Medicine , Mwanza , Tanzania

6. Flow Cytometry Core Laboratory, Weill Cornell Medicine , New York, New York , USA

7. Mwanza Intervention Trials Unit , Mwanza , Tanzania

8. Outbreak Research Team, Department of Public Health, Institute of Tropical Medicine , Antwerp , Belgium

9. Department of Cell and Chemical Biology, Leiden University Medical Center , Leiden, The Netherlands

Abstract

Abstract Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14+ monocytes in infected women.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofac657/47708227/ofac657.pdf

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