Comparing Polymerase Chain Reaction Testing of Nasopharyngeal Swab and Lower Respiratory Tract Specimens for the Diagnosis of <i>Pneumocystis jirovecii</i> Pneumonia-Reference-Cited by-同舟云学术

Comparing Polymerase Chain Reaction Testing of Nasopharyngeal Swab and Lower Respiratory Tract Specimens for the Diagnosis of Pneumocystis jirovecii Pneumonia

Published:2024-02-02 Issue:3 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Chew Rusheng¹²³^ORCID,Tozer Sarah⁴,Ulett Kimberly⁵,Paterson David L⁴⁶⁷,Whiley David⁶,Sloots Theo³,Fielding David³⁸,Zappala Christopher³⁸,Bashirzadeh Farzad⁸,Hundloe Justin⁸,Bletchley Cheryl⁴,Woods Marion L³⁷

Affiliation:

1. Centre for Tropical Medicine and Global Health, University of Oxford , Oxford , United Kingdom

2. Mathematical and Economic Modelling Department, Mahidol Oxford Tropical Medicine Research Unit , Bangkok , Thailand

3. Faculty of Medicine, University of Queensland , Brisbane , Australia

4. Central Laboratory, Pathology Queensland, Central Laboratory , Brisbane , Australia

5. Department of Medicine, Gold Coast Hospital and Health Service , Gold Coast , Australia

6. UQ Centre for Clinical Research, University of Queensland , Brisbane , Australia

7. Infectious Diseases Unit, Royal Brisbane and Women's Hospital , Brisbane , Australia

8. Department of Thoracic Medicine, Royal Brisbane and Women's Hospital , Brisbane , Australia

Abstract

Abstract Using nasopharyngeal (NP) swab samples instead of lower respiratory tract specimens for polymerase chain reaction (PCR) to diagnose Pneumocystis jirovecii pneumonia (PJP) may be better tolerated and improve diagnostic accessibility. In this 2-year Australian retrospective cohort study of patients with clinically suspected PJP, P jirovecii PCR on NP swab samples had perfect specificity but low sensitivity (0.66).

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae071/56554339/ofae071.pdf

Reference17 articles.

1. Pneumocystis jirovecii—from a commensal to pathogen: clinical and diagnostic review;Sokulska;Parasitol Res,2015

2. Current epidemiology of Pneumocystis pneumonia;Morris;Emerg Infect Dis,2004

3. Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study;Pneumonia Etiology Research for Child Health (PERCH) Study Group;Lancet,2019

4. Pneumocystis pneumonia in the twenty-first century: HIV-infected versus HIV-uninfected patients;Cillóniz;Expert Rev Anti Infect Ther,2019

5. Changing trends in the epidemiology and risk factors of Pneumocystis pneumonia in Spain;Pereira-Díaz;Front Public Health,2019

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development and validation of supervised machine learning multivariable prediction models for the diagnosis of Pneumocystis jirovecii pneumonia using nasopharyngeal swab PCR in adults in a low-HIV prevalence setting;International Health;2024-08-29