Successful Treatment of Persistent Symptomatic Coronavirus Disease 19 Infection With Extended-Duration Nirmatrelvir-Ritonavir Among Outpatients With Hematologic Cancer

Author:

Liu Catherine123ORCID,Yoke Leah H12,Bhattacharyya Pooja12,Cassaday Ryan D34,Cheng Guang-Shing35,Escobar Zahra Kassamali16,Ghiuzeli Cristina34,McCulloch Denise J123,Pergam Steven A123,Roychoudhury Pavitra17,Tverdek Frank16,Schiffer Joshua T123,Ford Emily S12

Affiliation:

1. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

2. Division of Allergy and Infectious Diseases, University of Washington , Seattle, Washington , USA

3. Clinical Research Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

4. Division of Hematology, University of Washington , Seattle, Washington , USA

5. Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington , Seattle, Washington , USA

6. School of Pharmacy, University of Washington , Seattle, Washington , USA

7. Department of Laboratory Medicine, University of Washington , Seattle, Washington , USA

Abstract

Abstract Persistent symptomatic coronavirus disease 2019 (COVID-19) is a distinct clinical entity among patients with hematologic cancer and/or profound immunosuppression. The optimal medical management is unknown. We describe 2 patients who had symptomatic COVID-19 for almost 6 months and were successfully treated in the ambulatory setting with extended courses of nirmatrelvir-ritonavir.

Funder

National Cancer Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference21 articles.

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