Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009

Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009–2018

Published:2020-07-18 Issue:8 Volume:7 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Eddy Jared J¹^ORCID,Gadani Kavita M²,Tibbs Andrew³,Bernardo John⁴⁵^ORCID,Cochran Jennifer⁴,White Laura F⁶^ORCID,Horsburgh C Robert⁷^ORCID,Jacobson Karen R¹^ORCID

Affiliation:

1. Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts, USA

2. Massachusetts Department of Public Health, Boston, Massachusetts, USA

3. Division of Global Populations, Massachusetts Department of Public Health, Boston, Massachusetts, USA

4. Division of Global Populations and Infectious Disease Prevention, Massachusetts Department of Public Health, Boston, Massachusetts, USA

5. Boston University School of Medicine, Boston, Massachusetts, USA

6. Department of Biostatistics, Boston University, Boston, Massachusetts, USA

7. Epidemiology, Biostatistics, Global Health and Medicine, Boston University Schools of Public Health and Medicine, Boston, Massachusetts, USA

Abstract

Abstract We examined Massachusetts tuberculosis surveillance data from to 2009 to 2018. Of 1533 culture-confirmed cases, 190 (12.4%) demonstrated resistance to isoniazid including 32 (2.1%) with rifampin resistance. In multivariable analysis, isoniazid resistance increased significantly over time (per-year odds ratio = 1.07, 95% confidence interval = 1.01–1.13, P = .018) and was associated with younger age, foreign birth, and prior tuberculosis treatment.

Funder

Boston University Clinical HIV/AIDS Research Training Program

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Providence/Boston Center for AIDS Research

Boston University/Rutgers Tuberculosis Research Unit

US-India Vaccine Action Program Initiative on Tuberculosis

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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