Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male-Reference-Cited by-同舟云学术

Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male

Published:2021-08-31 Issue:9 Volume:8 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Pham Khanh¹^ORCID,Gottesdiener Lee¹,Simon Matthew S¹²,Trzebucki Alex¹,Maldarelli Grace A¹,Cisse Babacar¹³,Lieberman Joshua⁴^ORCID,DeHaan Elliot¹²,Pisapia David¹⁵

Affiliation:

1. New York–Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USA

2. Department of Medicine, Weill Cornell Medicine, New York, New York, USA

3. Department of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA

4. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

5. Department of Pathology, Weill Cornell Medicine, New York, New York, USA

Abstract

Abstract We present a case of a human immunodeficiency virus–negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained from a brain biopsy demonstrated spirochetes consistent with Treponema pallidum and confirmed by 16S ribosomal RNA sequencing.

Funder

New York–Presbyterian Hospital and Weill Cornell Medical College

Clinical and Translational Science Center

Joint Clinical Trials Office

Research Training in Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofab455/40141550/ofab455.pdf

Reference28 articles.