Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019
Author:
Regan James1ORCID, Flynn James P1, Rosenthal Alexandra1, Jordan Hannah1, Li Yijia1ORCID, Chishti Rida1, Giguel Francoise2, Corry Heather1, Coxen Kendyll1, Fajnzylber Jesse1, Gillespie Elizabeth1, Kuritzkes Daniel R1, Hacohen Nir23, Goldberg Marcia B23, Filbin Michael R23, Yu Xu G124, Baden Lindsey1, Ribeiro Ruy M5, Perelson Alan S56, Conway Jessica M7, Li Jonathan Z1, Abayneh Betelihem A, Allen Patrick, Alter Galit, Antille Diane, Armstrong Katrina, Balazs Alejandro, Bals Julia, Barbash Max, Bartsch Yannic, Boucau Julie, Boyce Siobhan, Braley Joan, Branch Karen, Broderick Katherine, Carney Julia, Chan Andrew, Chevalier Josh, Chowdhury Fatema, Daley George, Davidson Susan, Dougan Michael, Drew David, Einkauf Kevin, Elliman Ashley, Fallon Jon, Fedirko Liz, Finn Kelsey, Flaherty Keith, Flannery Jeanne, Forde Pamela, Garcia-Broncano Pilar, Gettings Elise, Golan David, Griffin Amanda, Grimmel Sheila, Grinke Kathleen, Hall Kathryn, Hartana Ciputra, Healy Meg, Heller Howard, Henault Deborah, Holland Grace, Jiang Chenyang, Jilg Nikolaus, Kaplonek Paulina, Karpell Marshall, Kayitesi Chantal, Lam Evan C, LaValle Vlasta, Lefteri Kristina, Lian Xiaodong, Lichterfeld Mathias, Lingwood Daniel, Liu Hang, Liu Jinqing, Lu Yiting, Luthern Sarah, Ly Natasha, Marchewka Jordan, Martino Britanni, McNamara Roseann, Michell Ashlin, Millstrom Ilan, Miranda Noah, Nambu Christian, Nelson Susan, Noone Marjorie, O’Callaghan Claire, Ommerborn Christine, Osborn Mathew, Pacheco Lois Chris, Phan Nicole, Pillai Shiv, Porto Falisha A, Rassadkina Yelizaveta, Reissis Alexandra, Rosenthal Alex, Ruzicka Francis, Ryan Edward, Seiger Kyra, Selleck Kathleen, Sessa Libera, Sharpe Arlene, Sharr Christianne, Shin Sally, Singh Nishant, Slaughenhaupt Sue, Sheppard Kimberly Smith, Sun Weiwei, Sun Xiaoming, Suschana Elizabeth, Ticheli Hannah, Trocha-Piechocka Alicja, Wilson Vivine, Wong Colline, Worrall Daniel, Zhu Alex, Hill Zachary Manickas, Demers Edward, Judge Kelly, Walker Bruce, Lai Peggy, Li Jonathan, Ghebremichael Musie S,
Affiliation:
1. Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA 2. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 3. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 4. Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts, USA 5. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA 6. New Mexico Consortium, Los Alamos, New Mexico, USA 7. Department of Mathematics and Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, Pennsylvania, USA
Abstract
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.
Funder
Enid Schwartz Mark and Lisa Schwartz Foundation Massachusetts Consortium for Pathogen Readiness Ragon Institute of MGH, MIT and Harvard U.S. Department of Energy Los Alamos National Laboratory National Science Foundation National Institutes of Health
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
19 articles.
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