Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution-Reference-Cited by-同舟云学术

Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution

Published:2021-06-04 Issue:7 Volume:8 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Monrad Ida¹²,Sahlertz Signe Risgaard³,Nielsen Stine Sofie Frank¹²,Pedersen Louise Ørnskov⁴,Petersen Mikkel Steen⁴,Kobel Carl Mathias⁵,Tarpgaard Irene Harder⁵,Storgaard Merete¹,Mortensen Klaus Leth³,Schleimann Mariane H¹,Tolstrup Martin¹²,Vibholm Line K¹

Affiliation:

1. Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

2. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

3. Department of Medicine, Regional Hospital West Jutland, Herning, Denmark

4. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark

5. Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark

Abstract

Abstract We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.

Funder

RegionMidt/Aarhus University Hospital

Aarhus University

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofab295/38490243/ofab295.pdf

Reference20 articles.

1. Human neutralizing antibodies elicited by SARS-CoV-2 infection;Ju;Nature,2020

2. SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls;Le Bert;Nature,2020