Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus-Reference-Cited by-同舟云学术

Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus

Published:2023-03-01 Issue:3 Volume:10 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Schnittman Samuel R¹²^ORCID,Kitch Douglas W³,Swartz Talia H⁴,Burdo Tricia H⁵,Fitch Kathleen V²,McCallum Sara²,Flynn Jacqueline M⁵,Fulda Evelynne S²,Diggs Marissa R²,Stapleton Jack T⁶,Casado José L⁷,Taron Jana⁸⁹,Currier Judith S¹⁰,Zanni Markella V²,Malvestutto Carlos¹¹,Fichtenbaum Carl J¹²,Aberg Judith A⁴,Ribaudo Heather J³,Lu Michael T⁸,Douglas Pamela S¹³,Grinspoon Steven K²

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts , USA

2. Metabolism Unit, Massachusetts General Hospital , Boston, Massachusetts , USA

3. Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , USA

4. Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai , New York, New York , USA

5. Department of Microbiology, Immunology, and Inflammation and Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine , Philadelphia, Pennsylvania , USA

6. Division of Infectious Diseases, Department of Medicine, University of Iowa , Iowa City, Iowa , USA

7. Department of Infectious Diseases, Ramon y Cajal Health Research Institute (IRyCIS), University Hospital Ramon y Cajal , Madrid , Spain

8. Cardiovascular Imaging Research Center, Massachusetts General Hospital , Boston, Massachusetts , USA

9. Department of Radiology, Faculty of Medicine, Medical Center – University of Freiburg, University of Freiburg , Freiburg , Germany

10. Division of Infectious Diseases, Department of Medicine, University of California at Los Angeles , Los Angeles, California , USA

11. Division of Infectious Diseases, Department of Medicine, The Ohio State University Wexner Medical Center , Columbus, Ohio , USA

12. Division of Infectious Diseases, Department of Medicine, University of Cincinnati , Cincinnati, Ohio , USA

13. Duke Clinical Research Institute, Duke University School of Medicine , Durham, North Carolina , USA

Abstract

AbstractBackgroundInflammasome activation is increased in people with human immunodeficiency virus (PWH), but its relationship with coronary plaque is poorly understood in this setting.MethodsIn a large human immunodeficiency virus cardiovascular prevention cohort, relationships between caspase-1, interleukin (IL)-1β, and IL-18 and coronary plaque indices were assessed by multivariate logistic regression.ResultsHigher IL-18 and IL-1β were associated with Leaman score, an integrative measure of plaque burden and composition.ConclusionsAs Leaman score >5 is associated with cardiovascular events in the general population, future work is needed to determine how the inflammasome relates to events and whether strategies to reduce its activation affect events or plaque progression among PWH.

Funder

National Institutes of Health

National Institute of Heart, Lung, and Blood Institute

Kowa Pharmaceuticals America Inc.

Gilead Sciences

ViiV Healthcare

National Institute of Allergy and Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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