Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Author:

Ramírez Mena Adrià123,Thioubou Mame Aissé4,Diallo Kalilou5,Tine Judicaël1,Ngom Ndeye Fatou6,Fortes Louise1,Ndiaye Kiné6,Karasi Jean-Claude7,Seguin-Devaux Carole8,Goedertz Henri7,Diouf Daouda9,Seydi Moussa1,Sambou Benjamin Amaye9,Arendt Vic7,Wandeler Gilles1210,Manga Noël Magloire5,

Affiliation:

1. Department of Infectious and Tropical Diseases, Fann University Hospital , Dakar , Senegal

2. Department of Infectious Diseases, Bern University Hospital, University of Bern , Bern , Switzerland

3. Graduate School of Health Sciences, University of Bern , Bern , Switzerland

4. Department of Gastroenterology, Hôpital Universitaire de la Paix , Ziguinchor , Senegal

5. Department of Infectious Diseases, Hôpital Universitaire de la Paix , Ziguinchor , Senegal

6. Centre de Traitement Ambulatoire, Fann University Hospital , Dakar , Senegal

7. Department of Infectious Diseases, Centre Hospitalier du Luxembourg , Luxembourg , Luxembourg

8. Department of Infection and Immunity, Luxembourg Health Institute , Luxembourg , Luxembourg

9. ENDA (Environnement, Développement et Action) Santé , Dakar , Senegal

10. Institute of Social and Preventive Medicine, University of Bern , Bern , Switzerland

Abstract

Abstract The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.

Funder

Swiss National Science Foundation

Ministry of Foreign and European Affairs of Luxembourg

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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