Karius With a Q: Role for Microbial Cell-Free DNA Next-Generation Sequencing in Diagnosis of Acute Q Fever

Author:

Ranganath Nischal1ORCID,Khodadadi Ryan B1,Abu Saleh Omar M1

Affiliation:

1. Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic , Rochester, Minnesota , USA

Abstract

Abstract The diagnosis of Q fever can be challenging and a high index of suspicion is necessary. Within this case series, we highlight the utility of the microbial cell-free DNA next-generation sequencing or Karius Test in the timely diagnosis and management of acute Q fever.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference8 articles.

1. From Q fever to Coxiella burnetii infection: a paradigm change;Eldin;Clin Microbiol Rev,2017

2. Q fever: epidemiology, diagnosis, and treatment;Hartzell;Mayo Clin Proc,2008

3. Comparison of PCR and serology assays for early diagnosis of acute Q fever;Fournier;J Clin Microbiol,2003

4. Diagnosis and genotyping of Coxiella burnetii endocarditis in a patient with prosthetic pulmonary valve replacement using next-generation sequencing of plasma microbial cell-free DNA;Kondo;Open Forum Infect Dis,2019

5. Diagnosis and management of Q fever—United States, 2013: recommendations from CDC and the Q fever working group;Anderson;MMWR Recomm Rep,2013

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