The Syphilis Epidemic Among Heterosexuals Is Accelerating: Evidence From King County, Washington

Author:

Berzkalns Anna1,Ramchandani Meena S12,Cannon Chase A12,Kerani Roxanne P123,Dombrowski Julie C123,Golden Matthew R123

Affiliation:

1. HIV/STD/HCV Program, Public Health–Seattle & King County , Seattle, Washington , USA

2. Department of Medicine, University of Washington , Seattle, Washington , USA

3. Department of Epidemiology, University of Washington , Seattle, Washington , USA

Abstract

Abstract Background We characterized the rapid increase in syphilis among cisgender women in King County, Washington, and compared it with trends among cisgender men who have sex with men. Method We used surveillance data from King County, 2007 to 2022, to describe incidence trends stratified by syphilis stage, gender, and gender of sex partners; trends in pregnant cases and congenital syphilis; and trends in rapid plasma reagin titer at diagnosis among late/unknown duration cases. We used joinpoint regression to analyze trends. Results Among cisgender women, all-stage syphilis incidence remained stable from 2007 to 2010 but then increased by 16.3% per year (95% CI, 12.0%–20.7%) from 2010 to 2020 and 90.1% per year (95% CI, 26.4%–185.9%) from 2020 to 2022. Early syphilis rates rose gradually from 2007 to 2017 (18% per year; 95% CI, 7.4%–29.6%) and then rapidly from 2017 to 2022 (62.5% per year; 95% CI, 24.1%–112.9%). In contrast, the increase in late/unknown duration syphilis incidence was delayed. Among cisgender men who have sex with women, all-stage syphilis remained stable from 2007 to 2014 and increased 25.0% per year (95% CI, 14.0%–37.0%) from 2014 to 2022. Syphilis incidence increased steadily among men who have sex with men, with all-stage incidence increasing 7.0% per year (95% CI, 4.8%–9.2%) from 2007 to 2022. Median rapid plasma reagin titer among late/unknown duration cases increased significantly over the analysis period. Conclusions An explosive epidemic of syphilis is ongoing in King County. The delayed increase in asymptomatic late/unknown duration cases relative to early symptomatic cases suggests that there is a large and growing reservoir of recently acquired undiagnosed syphilis in women. New clinical and public health activities are urgently needed to control the growing epidemic.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference16 articles.

1. Epidemiology of primary and secondary syphilis in the United States, 1981 through 1989;Rolfs;JAMA,1990

2. Surveillance for primary and secondary syphilis—United States, 1991;Webster;MMWR CDC Surveill Summ,1993

3. Comparison of early and late latent syphilis–Colorado, 1991;Centers for Disease Control and Prevention;MMWR Morb Mortal Wkly Rep,1993

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3