Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus-Reference-Cited by-同舟云学术

Passively Acquired Constant Region 5–Specific Antibodies Associated With Improved Survival in Infants Who Acquire Human Immunodeficiency Virus

Published:2023-06-14 Issue:7 Volume:10 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Yaffe Zak A¹²³,Sung Kevin⁴,Bosire Rose⁵,Farquhar Carey⁶⁷⁸,Ngacha Dorothy Mbori⁹¹⁰,Lohman-Payne Barbara⁶⁸¹⁰,Nduati Ruth¹⁰,John-Stewart Grace⁶⁷⁸¹¹^ORCID,Matsen Frederick A⁴¹²,Overbaugh Julie¹⁴

Affiliation:

1. Human Biology Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

2. Molecular and Cellular Biology Program, University of Washington , Seattle, Washington , USA

3. Medical Scientist Training Program, University of Washington , Seattle, Washington , USA

4. Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

5. Centre for Public Health Research, Kenya Medical Research Institute , Nairobi , Kenya

6. Department of Global Health, University of Washington , Seattle, Washington , USA

7. Department of Epidemiology, University of Washington , Seattle, Washington , USA

8. Department of Medicine, University of Washington , Seattle, Washington , USA

9. HIV Section, United Nations Children's Fund , New York, New York , USA

10. Department of Paediatrics and Child Health, University of Nairobi, Kenyatta National Hospital , Nairobi , Kenya

11. Department of Pediatrics, University of Washington , Seattle, Washington , USA

12. Howard Hughes Medical Institute , Seattle, Washington , USA

Abstract

Abstract Studying vertical human immunodeficiency virus (HIV) transmission enables the impact of passively transferred antibodies on HIV transmission and pathogenesis to be examined. Using phage display of HIV envelope peptides and peptide enzyme-linked immunosorbent assay (ELISA), we found that, in infants who acquired HIV, passive antibody responses to constant region 5 (C5) were associated with improved survival in 2 cohorts. In a combined analysis, C5 peptide ELISA activity was correlated directly with survival and estimated infection time and inversely with set point viral load. These results suggest that preexisting C5-specific antibodies may be correlated with the survival of infants living with HIV, motivating additional research into their protective potential.

Funder

National Institutes of Health

Howard Hughes Medical Institute

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad316/50603370/ofad316.pdf

Reference15 articles.

1. Dynamics of maternal IgG antibody decay and HIV-specific antibody synthesis in infants born to seropositive mothers;Parekh;AIDS Res Hum Retroviruses,1993

2. Maternal antibody response at delivery and perinatal transmission of human immunodeficiency virus type 1 in African women;Lallemant;Lancet,1994

3. Passively transmitted gp41 antibodies in babies born from HIV-1 subtype c-seropositive women: correlation between fine specificity and protection;Diomede;J Virol,2012

4. Maternal HIV-1 envelope–specific antibody responses and reduced risk of perinatal transmission;Permar;J Clin Invest,2015

5. Maternal envelope gp41 ectodomain-specific antibodies are associated with increased mother-to-child transmission of human immunodeficiency virus-1;Naiman;J Infect Dis,2020

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Phage Immunoprecipitation and Sequencing—a Versatile Technique for Mapping the Antibody Reactome;Molecular & Cellular Proteomics;2024-09