Influence of Hepatitis C Coinfection and Treatment on Risk of Diabetes Mellitus in HIV-Positive Persons
Author:
Mocroft Amanda1ORCID, Lundgren Jens D2, Rockstroh Juergen K3, Aho Inka4, Wandeler Gilles5, Nielsen Lars6, Edwards Simon7, Viard Jean-Paul8, Lacombe Karine9, Fätkenheuer Gerd10, Guaraldi Giovanni11ORCID, Laguno Montserrat12, Llibre Josep13, Elinav Hila14, Flamholc Leo15, Gisinger Martin16, Paduta Dzmitry17, Khromova Irina18, Jilich David19, Rozplochowski Blazej20, Oprea Cristiana21, Peters Lars1, Harxhi A, Losso M, Kundro M, Schmied B, Zangerle R, Karpov I, Vassilenko A, Paduto D, Clumeck N, De Wit S, Delforge M, Florence E, Vandekerckhove L, Hadziosmanovic V, Begovac J, Machala L, Jilich D, Sedlacek D, Kronborg G, Benfield T, Gerstoft J, Katzenstein T, Pedersen C, Johansen I S, Ostergaard L, Wiese L, Moller N F, Zilmer K, Aho I, Viard J-P, Girard P-M, Pradier C, Fontas E, Duvivier C, Rockstroh J, Behrens G, Degen O, Stellbrink H J, Bogner J, Fätkenheuer G, Chkhartishvili N, Sambatakou H, Adamis G, Paissios N, Szlávik J, Gottfredsson M, Kelly C, Tau L, Turner D, Burke M, Shahar E, Hassoun G, Elinav H, Haouzi M, Elbirt D, D’arminio Monforte A, Esposito R, Mazeu I, Mussini C, Mazzotta F, Gabbuti A, Lazzarin A, Castagna A, Gianotti N, Galli M, Ridolfo A, Uzdaviniene V, Matulionyte R, Staub T, Hemmer R, Dragas S, Stevanovic M, Reiss P, Trajanovska J, Reikvam D H, Maeland A, Bruun J, Knysz B, Gasiorowski J, Inglot M, Bakowska E, Flisiak R, Grzeszczuk A, Parczewski M, Maciejewska K, Aksak-Was B, Beniowski M, Mularska E, Jablonowska E, Kamerys J, Wojcik K, Mozer-Lisewska I, Rozplochowski B, Zagalo A, Mansinho K, Maltez F, Oprea C, Yakovlev A, Khromova I, Kuzovatova E, Borodulina E, Vdoushkina E, Ranin J, Tomazic J, Miro J M, Laguno M, Martinez E, Garcia F, Blanco J L, Martinez-Rebollar M, Mallolas J, Callau P, Rojas J, Inciarta A, Moreno S, Clotet B, Jou A, Paredes R, Puig J, Llibre J M, Santos J R, Domingo P, Gutierrez M, Mateo G, Sambeat M A, Laporte J M, Falconer K, Thalme A, Sonnerborg A, Treutiger C J, Flamholc L, Scherrer A, Weber R, Cavassini M, Calmy A, Furrer H, Battegay M, Schmid P, Kuznetsova A, Mikhalik J, Sluzhynska M, Milinkovic A, Johnson A M, Simons E, Edwards S, Phillips A, Johnson M A, Mocroft A, Winston A, Clarke A, Leen C, Karpov I, Losso M, Lundgren J, Rockstroh J, Aho I, Rasmussen L D, Svedhem V, Wandeler G, Pradier C, Chkhartishvili N, Matulionyte R, Oprea C, Kowalska J D, Begovac J, Miró J M, Guaraldi G, Paredes R, Wandeler G, Paredes R, Kirk O, Peters L, Bojesen A, Raben D, Hansen E V, Kristensen D, Larsen J F, Fischer A H, Mocroft A, Phillips A, Cozzi-Lepri A, Amele S, Pelchen-Matthews A, Roen A,
Affiliation:
1. Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK 2. CHIP, Rigshospitalet, Copenhagen, Denmark 3. University Hospital Bonn, Bonn, Germany 4. Helsinki University Hospital, Helsinki, Finland 5. Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland 6. Nordsjællands Hospital, Hillerød, Denmark 7. Mortimer Market Centre, London, UK 8. Hôtel-Dieu, AP-HP, Paris, France 9. Sorbonne Université, IPLESP Inserm UMR-S1136, AP-HP, Paris, France 10. University Hospital of Cologne, Cologne, Germany 11. University of Modena and Reggio Emilia, Modena, Italy 12. Hospital Clinic, Barcelona, Spain 13. University Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain 14. Hadassah Hospital, Jerusalem, Israel 15. Skane University Hospital, Malmö, Sweden 16. Medical University of Innsbruck, Innsbruck, Austria 17. Gomel Regional Centre for Hygiene, Gomel, Belarus 18. Centre for HIV/AIDS & Infectious Diseases, Kaliningrad, Russia 19. Charles University in Prague and Na Bulovce Hospital, Prague, Czech Republic 20. Poznan University of Medical Sciences, Poznan, Poland 21. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Abstract
AbstractBackgroundThe role of hepatitis C virus (HCV) coinfection and HCV-RNA in the development of diabetes mellitus (DM) in HIV-positive persons remains unclear.MethodsPoisson regression was used to compare incidence rates of DM (blood glucose >11.1 mmol/L, HbA1C >6.5% or >48 mmol/mol, starting antidiabetic medicine or physician reported date of DM onset) between current HIV/HCV groups (anti-HCV-negative, spontaneously cleared HCV, chronic untreated HCV, successfully treated HCV, HCV-RNA-positive after HCV treatment).ResultsA total of 16 099 persons were included; at baseline 10 091 (62.7%) were HCV-Ab-negative, 722 (4.5%) were spontaneous clearers, 3614 (22.4%) were chronically infected, 912 (5.7%) had been successfully treated, and 760 (4.7%) were HCV-RNA-positive after treatment. During 136 084 person-years of follow-up (PYFU; median [interquartile range], 6.9 [3.6–13.2]), 1108 (6.9%) developed DM (crude incidence rate, 8.1/1000 PYFU; 95% CI, 7.7–8.6). After adjustment, there was no difference between the 5 HCV strata in incidence of DM (global P = .33). Hypertension (22.2%; 95% CI, 17.5%–26.2%) and body mass index >25 (22.0%; 95% CI, 10.4%–29.7%) had the largest population-attributable fractions for DM.ConclusionsHCV coinfection and HCV cure were not associated with DM in this large study. The biggest modifiable risk factors were hypertension and obesity, and continued efforts to manage such comorbidities should be prioritized.
Funder
Swiss National Science Foundation Danish National Research Foundation International Cohort Consortium of Infectious Disease
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
1 articles.
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