SARS-CoV-2 Omicron sub-variant Neutralization following a primary vaccine series of NVX-CoV2373 and BNT162b2 monovalent booster vaccine

Author:

Babu Tara M1ORCID,Shen Xiaoying2,McClelland R Scott134,Wang Zijun5,Selke Stacy1,Wilkens Chloe1,Hauge Kirsten A1,McClurkan Christopher L1,Goecker Erin1,Laing Kerry J1,Koelle David M13678,Greninger Alexander L67,Nussenzweig Michel C59,Montefiori David C210,Corey Lawrence167,Wald Anna1467

Affiliation:

1. Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington , Seattle, WA , USA

2. Department of Surgery, Duke University Medical Center , Durham, NC , USA

3. Department of Global Health, University of Washington , Seattle , USA

4. Department of Epidemiology, University of Washington , Seattle , USA

5. Laboratory of Molecular Immunology, The Rockefeller University , New York, NY , USA

6. Department of Laboratory Medicine and Pathology, University of Washington , Seattle, WA , USA

7. Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center , Seattle, WA , USA

8. Benaroya Research Institute , Seattle, Washington , USA

9. Howard Hughes Medical Institute, The Rockefeller University , New York, NY , USA

10. Duke Human Vaccine Institute, Duke University Medical Center , Durham, NC , USA

Abstract

Abstract We evaluated the immunologic response to a novel vaccine regimen that included two doses of NVX-CoV2373 (Novavax) followed by 1 dose of BNT162b2 (Pfizer-BioNTech) monovalent booster vaccine. A durable neutralizing antibody response to Omicron BA.4/BA.5 and BA.1 variants was observed at month 6 post-booster, while immune escape was noted for the XBB.1.5 variant.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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